74 NATURALS
particular, statistically significant results were obtained after 28 days on thighs and gluteus and after 56 days on arms (p< 0.05). Citrus bergamia extract demonstrated to act on different cutaneous areas enhancing their firmness. As regards R2 parameter, statistically significant results (p< 0.05) were recorded after just 14 days of treatment on thighs and gluteus and after 28 days on arms (p< 0.05). Recorded values of R6 show that the
formula with Citrus bergamia extract is more effective than placebo in improving the elasticity. Statistically significant results (p< 0.05) were recorded after 2 weeks on thighs and gluteus and the values became highly statistically significant (p< 0.001) after 4 weeks. On arms the different activity between
active formula and placebo was statistically significant after 56 days (p< 0.05).
Expert scoring
Expert scoring scale was based on five key morphological clinical features: Number of evident depressions Depth of depressions Morphological appearance of skin surface alterations
Grade of laxity, flaccidity or sagging skin Classification scale of cellulite stage Visual scores were attributed by the dermatologist and results are hereafter expressed as percentage of subjects that showed improvements:
Formula with Citrus bergamia extract caused an improvement in 10% of subjects after 14 days, in 55% after 28 days and in 80% after 56 days;
Placebo caused an improvement in 5% of subjects after 14 days, in 20% after 28 days and in 40% after 56 days.
Self-assessment of the panellists Volunteers reported very good feedbacks about the active product. After just two weeks of treatment 80% of subjects reported an improvement of skin elasticity, 85% declared to feel the skin smoother and 55% judged positively the remodelling effects of the product on the investigated areas.
Conclusion Obtained results show that Flavoslim was able to reduce cellulite-derived skin imperfections and to produce a significant slimming and remodelling effect in the investigated areas. The formulation with Flavoslim at 1.5% caused a better thermal homogeneity than placebo, thus the active extract was capable of improving blood and lymphatic microcirculation. Active formula had also a remarkable
effect on the superficial adipose tissue of all cutaneous sites controlled (starting from 28 days of product use). The ability of
PERSONAL CARE EUROPE
Flavoslim to reduce the thickness of the adipose tissue was higher than the placebo. The slimming properties of Flavoslim
were highlighted with a decrease in thigh and arm circumference. Reduction of the girth is the result of the effect on oedema and on the fat layer and Flavoslim demonstrated to work on both sides, improving microcirculation and acting as a lipolytic agent. It is noteworthy that significant results were obtained in just 14 days of treatment. Furthermore, results highlighted the ability of Flavoslim to improve the skin elasticity at different levels. In fact, it strengthens skin firmness, increases the cutaneous ability to return to the basal state and, reducing water retention, increases dermal elasticity. It is important to emphasize that Flavoslim demonstrated its efficacy in different cutaneous areas. Each skin area is characterised by its own elasticity, therefore responds in a different way to the treatments. Therefore, Flavoslim is a suitable
ingredient for cosmetic products aimed at improving the signs of cellulite and at perfecting body silhouette and tone. It can be used both in conventional and organic formulations since it is ECOCERT and COSMOS approved.
PC
References 1 Terranova F, et al. Cellulite: nature and aetiopathogenesis. International Journal Of Cosmetic Science 2006; 28: 157-167
2 Leszko M. Cellulite in menopause. Prz Menopauzalny 2014; 13(5): 298-304
3 Benavente-Garcia O, Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti- inflammatory activity. J. Agric. Food Chem. 2008; 56: 6185–6205.
4 Manthey JA; Grohmann K, Guthrie,N. Mean reduction of SAT thickness on arms T14 0
-0.05 -0.1 -0.15 -0.2 -0.25 -0.3
Time (dd) T28
T56
-0.05 -0.1
-0.06 -0.11
-0.2* -0.25* Placebo Citrus bergamia ext. Figure 7: The graph reports the mean variation versus T0 at each checkpoint for the SAT thickness on arms.
Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr. Med. Chem. 2001; 8: 135–153.
5 Manthey JA. Biological Properties of Flavonoids Pertaining to Inflammation, Microcirculation 2000; 7:sup1, S29-S34
6 Arct J et al. Flavonoids as components of biologically active cosmeceuticals. Clinics in Dermatology 2008; 26: 347–357
7 Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M. Antioxidant and anti- inflammatoryproperties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecularmechanisms and experimental models. Phytother. Res. 2015; 29: 323–331.
8 Ferlazzo N, et al. Flavonoid fraction of orange and bergamot juices protect human lung epithelial cells from hydrogen peroxide- induced oxidative stress. Evid. Based Complement. Alternat. Med. 2015: 957031
9 Ferlazzo N et al. Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand? Molecules 2016; 21: 1273;
10 Risitano R, et al. Flavonoid Fraction of Bergamot Juice Reduces LPS Induced Inflammatory Response through SIRT1- Mediated NF-kB Inhibition in THP-1 Monocytes. PLoS ONE 2014; 9: (9).
11 Graziano A, et al. Protective effects of an extract from Citrus bergamia against inflammatory injury in interferon-gamma and histamine exposed human keratinocytes. Life Sciences 90 2012; 968–974.
12 Chin-Lin HSU et al. Effects of Flavonoids and Phenolic Acids on the Inhibition of Adipogenesis in 3T3-L1 Adipocytes. J. Agric. Food Chem. 2007; 55: 8404–8410
13 Lo Furno et al. A Citrus bergamia Extract Decreases Adipogenesis and Increases Lipolysis by Modulating PPAR Levels in Mesenchymal Stem Cells from Human Adipose Tissue. PPAR Research 2016; 1-9.
April 2019
Variation vs T0
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