SKIN PROTECTION 67
desquamation in vivo: The in vivo study has been performed in accordance with the principles of good laboratory practice (GLP), good clinical practice (GCP), and in compliance with the quality assurance system requirements. The study was conducted in accordance with the World Medical Association’s Declaration of Helsinki. All study participants signed a written informed consent at the beginning of the study. 20 female subjects, all with healthy, Caucasian skin, aged 20 - 46 years (average 30.6 years) applied twice daily an emulsion containing 0% active (placebo) or 3% active on the hemiface in a double- blind, placebo-controlled, randomised study. For desquamation measurements, corneocytes were detached from the face with Corneofix®
F20 desquamation
collector foil at day 0 and day 28 and the mass of the collected corneocytes was measured. The collected corneocytes were then used for the Lipid Peroxidation (MDA) Assay Kit in order to measure levels of lipid peroxides.
Results T. obliquus carotenoids absorb HEV light HEV or blue light induces ROS in the skin barrier and in skin cells. T. obliquus carotenoids absorb blue light in the range 400 - 480 nm, which represents the high
ROS generation in Keratinocytes exposed to WiFi field % from baseline (vehicle control WiFi off)
40 30 20 10 0
-10 -20
-71% ***
-73% ***
** *
Mean + SEM; n=12;
* = p<0.05 ** = p<0.01 *** = p<0.001
* WiFi off WiFi 0.5 mW WiFi 50 mW
Figure 8: T. obliquus carotenoids reduce ROS generated in a WiFi field. Internal ROS production in keratinocytes irradiated with different intensities of WiFi radiation was measured. Internal ROS were quenched significantly by 10.9% without radiation (WiFi off). On exposure to a WiFi field, the generation of ROS increased with field intensity by up to +25% at 50 mW. T. obliquus carotenoids reduced this extra ROS load by more than 70%. Unpaired Student’s t-test.
energy fraction of visible light, directly adjacent to UVA light (Fig 3). This means they can act in principle as a blue light filter. In final cosmetic formulations at a concentration of 1 – 5%, the level of
absorption will be reduced. Hence it can be assumed that in the final product, the ROS-eliminating capacity of the carotenoids will predominate over the beneficial effect attributable to screening
***
Vehicle control T.obliquus carotenoid 0.005%
Natural Cosmetic Ingredient
WINNER PCHi 2019
In PCHi China 2019, “Wamino-BonBon” received R&D Award
＜Molasses, Oryza Sativa (Rice) Lees Extract＞
The combination of ingredients indigenous to Japan helps create a good feeling to skin, hair and formulation.
Japanese Sake lees (Sake-kasu) Wamino-BonBon is listed in the Inventory of Existing Cosmetic Ingredient in China 2015. The leading natural ingredient manufacturer for the cosmetic industry
318-1, Asagi, Motosu-shi, Gifu 501-0475 JAPAN Phone: +81(0) 58 320-1032 FAX: +81(0) 58 320-1039 e-Mail :
info@ichimaru.co.jp Official Website :
www.ichimaru.co.jp/english
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PERSONAL CARE EUROPE
IECIC 2015
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