SKIN PROTECTION 69 Increase in barrier strength Relative to initial condition (%) 100 p=0.2 75 * 50 ***
Placebo RADICARE -GOLD 3%
13 Darvin ME, Fluhr JW, Caspers P, et al. In vivo distribution of carotenoids in different anatomical locations of human skin: comparative assessment with two different Raman spectroscopy methods. Experimental Dermatology. 2009;18(12):1060-3.
14 Darlenski R, Fluhr JW. In vivo Raman spectroscopy in the investigation of the skin barrier. In: T. A, editor. Current problems in dermatology: Skin barrier function. 49. Basel, New York: Karger; 2016.
15 Vandersee S, Beyer M, Lademann J, Darvin ME. Blue-violet light irradiation dose dependently decreases carotenoids in human skin, which indicates the generation of free radicals. Oxid Med Cell Longev. 2015;2015:579675.
25
Mean + SEM; n=20;
0
* = p<0.05 *** = p<0.001
Figure 10: Increase in the epidermal barrier strength on the face. Skin treated with the active showed a significantly increased barrier strength compared to initial condition and outperformed placebo. Two- tailed, paired Student’s t-test.
stratum corneum. This results in damage to the skin barrier, increased corneocyte detachment and reduced hydration. At the intracellular level, these forms of radiation can either directly provoke ROS formation or influence this by exciting
photosensitisers, which transfer their energy to create ROS. Besides UV and HEV light, other radiation sources in modern technology or simply stress can increase the level of ROS by putting pressure on the respiratory chain in the mitochondrial membrane so that it leaks electrons, which are the main source of intracellular ROS production. Radicare-Gold adds valuable antioxidants in the form of β–carotene and lutein to the skin barrier and the living cells. Both molecules can eliminate ROS at an early stage by neutralising excited molecular states, both in the skin barrier and in living cells, acting synergistically. They prevent leaked electrons combining with atmospheric oxygen at the ROS formation stage, especially in the sensitive biomembranes. In this way, Radicare-Gold provides for a robust skin barrier on the outside but also on the inside, protecting the skin against ROS-induced premature skin ageing provoked by all kinds of radiation.
PC
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PERSONAL CARE EUROPE
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