TESTING The various in vitro measurement methods
are on the rise and will become increasingly important in the future. There is hardly any major CRO (contract research organization) for cosmetics and pharmaceutical products that does not already offer such tests. We are excited to see what else can be researched using in vitro methods, especially in combination with AI. Above all, the laboratory animals will appreciate it!
References 1. Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. Official Journal of the European Union. L 342/59, 2009/12/22. https://health.
ec.europa.eu/system/files/2016-11/ cosmetic_1223_2009_regulation_ en_0.pdf
2. OECD Guideline 428 for the Testing of Chemicals – Skin Absorption: in vitro Method. 23 November 2004. https://
www.oecd-ilibrary.org/environment/ test-no-428-skin-absorption-in-vitro- method_9789264071087-en
3. OECD (2010). Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
4. OECD (2019). Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method, OECD Guidelines for the Testing of Chemicals, Section 4
5. OECD (2023). Test No. 442E: In Vitro Skin Sensitisation: In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for Skin Sensitisation. OECD Guidelines for the Testing of Chemicals, Section 4
6. Pinnagoda J, Tupker RA, Agner T, Serup J.
Figure 6: The new C+K CellSpectrometer CSM 2100 measuring a full impedance spectrum in 24 wells in less than two minutes
Guidelines for transepidermal water loss (TEWL) measurement. A report from the Standardization Group of the European Society of Contact Dermatitis, Contact Dermatitis. 1990 Mar, 22(3):164-78
7. Rogiers V/EEMCO Group. EEMCO Guidance for the Assessment of Transepidermal Water Loss in Cosmetic Sciences. Skin Pharmacology and Applied Skin Physiology. 2001; 14 (2): 117–128
8. Berardesca E, Loden M, Serup J, Masson P, Rodrigues LM. The revised EEMCO guidance for the in vivo measurement of water in the skin. Skin Research & Technology. 2018;24:351–358
9. Schoenfelder H, Liu Y, Lunter DJ. Systematic investigation of factors, such as the
impact of emulsifiers, which influence the measurement of skin barrier integrity by in-vitro trans-epidermal water loss (TEWL). International Journal of Pharmaceutics. 638 (2023) 122930
10. COLIPA Guidelines for the Evaluation of the Efficacy of Cosmetic Products. May 2008.
https://eu-ecolabel.de/fileadmin/user_ upload/Documents/PG006-039_7PG_/ PG030/Beschl%C3%BCsse-DE-EN/ Colipa_Guidelines_Efficacy_-_Revised_-_5_ May_2008.pdf
11. Wiora G, Knetzger N, Groeber-Becker F-K, Lotz C. Ultrasensitive impedance spectroscopy to replace the Draize eye test. Presentation at the 33rd IFSCC Congress, Barcelona, 4-7 September 2023
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www.personalcaremagazine.com April 2024 PERSONAL CARE
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