68 BIOTECHNOLOGY D0 D56


Figure 5: Visible light images of volunteer no. 1 on Day 0 vs. Day 56 of treatment with 2% of the studied endophytic extract (active)


analysis indicates that the active ingredient positively influences the endogenous lipidome profile by promoting longer chain lipids, particularly ceramides such as CER[NS]. This modulation of the whole lipidome enhances the skin barrier’s protective function against environmental pollutants, contributing to the restructuring of youthful and healthy skin.9


In vivo: quantifying the well-ageing power by instrumental analysis This in vivo double-blind hemi-face study investigated the efficacy of the active ingredient compared to a placebo. Conducted with a panel of 60 women aged 45-65, and living in a polluted area, the study focused on addressing visible ageing effects, particularly in post- menopausal skin. Through instrumental analyses, the research


aimed to quantify key parameters for skin ageing, offering insights into its potential in combating age-related skin concerns. The results at day 56 of the various instrumental tests performed (Figure 5) prove that the active significantly promotes (*p<0.5; **p<0.01; ***p<0.001; ****p<0.0001): ■ -3.9%*** TEWL (& -5.2%** in post- menopausal group) ■ +16.6%**** brightness (+21.0%**** in post- menopausal group) ■ -4.5*** colour variation (-6.6%** in post- menopausal group) ■ +4.3%*** microstructure (+5.3%* in post- menopausal group) ■ -7.5%* elastic fatigue ■ +5.8%** elastic recovery ■ -7.6%**** wrong fibre disposition Plus, a subjective assessment questionnaire


was performed after 28 and 56 days of product application, to gauge the volunteers’ perceptions. Notably, statistically significant positive responses were observed concerning “skin texture improvement” and “reduction in signs of ageing” (youthfulness).


PERSONAL CARE April 2024


Conclusion Aligned with its values, Provital introduces Shiloxome, a revolutionary active that honors interkingdom relationships, ushering in a new era of “ecosystem ingredients.” This fermented marvel, derived from the endophyte Kwoniella mangroviensis, embodies age-defying benefits while restructuring the skin barrier. Crafted through Triplobiome technology,


it seamlessly integrates the wisdom of ancient data transfer within organisms and microorganisms, fostering unprecedented symbiotic synergies for greater cosmetic benefits.


The active ingredient orchestrates a


symphony of natural elements to deliver a comprehensive multi-ome protection for the skin, adhering to the principles of the evolving field of holistic barrier care. Backed by exposomics research, the ingredient shields the skin from environmental pollutants, while protecting the microbiome barrier diversity. Transcriptomic research affirms its ability to


stimulate crucial cellular processes, ensuring a youthful and healthy extracellular matrix. And finally, its innovative lipidome analysis further underscores the new active ingredient’s positive impact on the skin barrier, promoting longer endogenous lipid chains and enhancing the skin barrier’s protective function. In essence, this new active ingredient


epitomizes Provital’s dedication to transformative skincare technology. With its symbiotic origin – the innovative Triplobiome technology – and high-tech proven efficacy, Shiloxome emerges as a potent ally in the pursuit of resilient and youthful skin, marking a paradigm shift in the well-ageing cosmetic sector.


secondary metabolites. Microbial Cell Factories. 2023; vol. 22


2. Keller A. Focus On Barrier Support To Improve Skin Health - Skin protection expands to restore and maintain a strong barrier as consumers prioritize overall skin health. Mintel. 2023.


3. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell. Res. 1965;37(3):614–36


4. Joshua Cameron D, Tong Z, Yang Z, Kaminoh J, Kamiyah S, Chen H et al. Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int. J. Biol. Sci. 2007;3


5. Li W, Sandhoff R, Kono M, Zerfas P, Hoffmann V, Char B et al. Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice. Int. J. Biol. Sci. 2007;3


6. Tawada C, Kanoh H, Nakamura M, Mizutani Y, Fujisawa T, Banno Y et al. Interferon-γ decreases ceramides with long-chain fatty acids: Possible involvement in atopic dermatitis and psoriasis. Journal of Investigative Dermatology. 2014;134(3):712–8


7. Janssens M, Van Smeden J, Gooris GS, Bras W, Portale G, Caspers PJ et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J. Lipid. Res. 2012 Dec;53(12):2755–66


PC


References 1. Kumari P, Deepa N, Trivedi PK, Singh BK, Srivastava V, Singh A. Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important


8. Kendall AC, Pilkington SM, Wray JR, Newton VL, Griffiths CEM, Bell M et al. Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy. Sci. Rep. 2022 Dec 1;12(1)


9. Eui Kim B, Kim J, Goleva E, Berdyshev E, Lee J, Vang KA et al. Particulate matter causes skin barrier dysfunction. JCI Insight. 2021


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