MARINE INGREDIENTS
NovelAlteromonas for tackling wrinkles
Míriam Mateu-Fibla, Elaine Ferreira, Ariadna Grau-Campistany, Andrea Esplugas, Silvia Pastor – LipoTrue
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If we consider that about a million microorganisms may exist in just one millilitre of seawater, we can only imagine how diverse marine ecosystems can be. This great biodiversity has attracted scientists to study the different species of microorganisms inhabiting in the oceans. Their role in the ecosystems, how they
interact with each other and with other marine species, and how they survive and adapt to the environment, help us to understand our evolution and identify environmental shifts. Hence, marine science is a key pillar in the research field. Research and innovation are close travel
companions that help push the limits of the cosmetic industry in pursuit of novel active ingredients that meet the ever-changing market demands. Companies constantly come up with novel mechanisms of action, efficacy claims, origins, and even cutting-edge technology. Yet what about discovering a new marine microorganism? The number of undiscovered
microorganisms in the oceans is considered to be huge, since identifying them is difficult because most of them are nearly impossible to cultivate in the laboratory to begin with.
Discover, develop, deliver V/WA™, the market’s first vertically integrated active ingredient, has born from the desire to push the boundaries of innovation even further. Lipotrue manages and owns the
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whole process, from identifying a new strain to developing and delivering a unique active ingredient to cosmetic manufacturers. The ingredient is obtained from
the fermentation of a newly identified Alteromonas species: Alteromonas lipotrueae. This microorganism was collected from the surface of the Mediterranean Sea’s most stinging jellyfish, the Pelagia noctiluca. It was then identified by 16S rRNA and
genomic analysis and deposited in two international culture collections to ensure its perpetuation and to contribute to the scientific community. The discovery was published in the Systematic and Applied Microbiology journal in 2021 (Figure 1).1
The ferment’s exometabolomic profile
indicated that it includes several biomimetic compounds with potential benefits for neuron- muscle communication as well as other anti- ageing properties. Based on these findings, we conducted numerous qPCRs to predict the likely mechanism of action, which revealed that it modulated several genes involved in neuritogenesis, synaptic transmission, and muscular contraction.
Expression lines: a holistic approach Expression wrinkles in the forehead, between the eyebrows, and around the eyes are a common source concern for many people since they might appear tired or aged. People nowadays take better care of their skin, so these fine lines are less evident when not making any expressions, but they appear when we smile or frown. Expression lines form as a result of
repetitive contractions of facial muscles. Each muscle fiber is typically innervated by a single motor axon. Muscle contraction starts when a neuron receives a chemical signal that causes a change in its membrane potential (depolarization), which is then transformed into an action potential that travels down the axons.
Then, a calcium influx induces synaptic
Figure 1: Scanning electron microscopy (SEM) image of Alteromonas lipotrueae
vesicles to fuse with the presynaptic membrane, allowing neurotransmitters like acetylcholine (ACh) to be released into the synaptic cleft. Afterwards, ACh travels to the
April 2024 PERSONAL CARE
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