122 ANTI-AGEING
Control (Day 10)
extract reduced wrinkle volume and the depth of crow’s feet as compared to using the placebo cream. These improvements can be clearly seen after two months in the before and after photos of a 58-year-old volunteer (Image 4).
Sustainability Because Epilobium fleischeri extract is an organic extract of a rare alpine plant growing on ancient glacier moraines, it is highly important that it is ethically produced, with a positive social impact and a low environmental impact. Epilobium fleischeri is harvested three times per year, which allows for very efficient use of the land. Organic cultivation and sustainable land
use are optimised to ensure that this Cosmos, Natrue-certified ingredient, is preserving Swiss alpine biodiversity. The cultivation of Epilobium fleischeri follows regenerative farming practices that are aligned with the Union
12 10 8 6 4 2 0
*p<0.05
Eterwell™ Youth (Day 10) Image 3: The effect of Epilobium fleisheri dry extract treatment on a skin explant taken from a 60 year-year-old female volunteer
Ethical BioTrade’s (UEBT) regenerative farming, which goes beyond responsible sourcing and ethical practices and focuses on improved soil restoration, water purification, the maintenance of biodiversity, and enhanced climate resilience. There is a fair-for-life, Fairtrade-certified
transparent and traceable supply chain from seed to bioactive, ensuring responsible sourcing. Also, DSM-Firmenich’s ethical relationships with small stakeholders guarantee a minimum price for farmers, which is fixed before harvest. With production requiring less than 3 kg of CO2
eq/kg, Epilobium fleischeri
extract has a low carbon footprint from cradle to gate. This and applying green chemistry principles to a gentle extraction process using organic ethanol limits its environmental impact.
Conclusion Recent research in senolytic science shows that by eliminating senescent skin cells, the
Epidermis: p16 immunostaining day 10 * * * - Control
Epilobium fleischeri dry extract
Navit *p<0.05
Figure 10: Histological immunostain intensity for p16, on day 10 following Epilobium fleischeri dry extract treatment on explant tissue taken from a 60-year-old-female skin
PERSONAL CARE April 2024
12 10 8 6 4 2 0
skin can become healthier and more youthful. The accumulating burden of senescent zombie cells and their inflammatory, tissue-damaging secretions is now recognized as a root cause of many of the characteristics of skin ageing, including sagging skin, wrinkles, the loss of skin elasticity and firmness, skin roughness, and a dull complexion. The exciting data presented here and the
more impressive results of in vivo studies on skin texture, skin structure, and wrinkles that are soon to be published demonstrate that Epilobium fleischeri extract acts as a natural senolytic, selectively inducing apoptosis only in senescent fibroblasts. This targeted removal of zombie cells allows the skin to regain youthful function and a youthful appearance. In vitro and ex vivo studies confirm the
senolytic activity of Epilobium fleischeri extract. When a cream with 3% Epilobium
Epidermis: p21 immunostaining day 10 *
*
*
- Control
Epilobium fleischeri dry extract
Navit
Figure 11: Histological immunostain intensity for p21, on day 10 following Epilobium fleischeri dry extract treatment on explant tissue taken from a 60-year-old-female skin
www.personalcaremagazine.com
Cell viability Surface (%)
Cell viability Surface (%)
DMSO 0.0048 0.0024 0.072 0.12 50μM
DMSO 0.0048 0.0024 0.072 0.12 50μM
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