60 SKIN CARE


Lysolecithin ingredient to restore sensitive skin


Catheleen Anne Ysulat, Harumi Suzuki, Shodai Ushijima, Satoshi Yoshimoto - Nikko Chemicals


The number of people suffering from sensitive skin caused by atopic dermatitis, allergies, air pollutants, temperature changes and stress is increasing, and sensitive skin cosmetics that claim low irritation and skin barrier repair have become essential products for such people. According to ‘The prevalence of sensitive


skin’, 60-70% of women and 50-60% of men report having some degree of sensitive skin on surveys conducted in 20 different countries in five continents.1 Furthermore, in recent years, harsh skin care routines have spread among GenZ and Millennials,


and many consumers’ skin has become thinner with weakened barrier function due to the side effects of peeling and care with retinol. As of February, there were 1.77 million posts about #sensitiveskin and 540,000 posts about #skinbarrierrepair on Instagram. Meanwhile, #sensitiveskin has been tagged over 122,000 times on TikTok. These are not only patients with atopic dermatitis, but also people with originally healthy skin conditions are starting to suffer from sensitive skin. The growing demand for truth-based and scientific evidence is pushing the


rise of clinically proven ingredients. The lysophosphatidic acid introduced here is rooted in long term scientific studies and addresses a wide range of skin barrier disorders to recover sensitive skin. In this article, we named the skin benefits from Nikkol Lecinol MFL (INCI: Lysolecithin).


Optimized product of lysophosphatidic acid for cosmetics One way to improve the skin barrier is to increase the barrier component derived from keratinocytes that can help in retaining the moisture in the skin. We are especially focused on lysophosphatidic acid, which is a type of lecithin, because our body originally uses lysophosphatidic acid as a support system for the skin barrier. It has long been known that lysophosphatidic


acid regulates the fate of keratinocytes (e.g. differentiation, migration, proliferation), and contribute to the construction of skin barrier. Literature on such skin wound healing has been published since the 1990s. Therefore, we have newly developed a lysolecithin ingredient containing lysophosphatidic acid as the active substance, using a ‘whole-cell enzyme technology’. Bioprocessing technology that uses enzymes


and other beneficial biological reactions have mild manufacturing conditions compared to chemical reactions and are a promising technology for realizing a ‘recycling society’. The lysolecithin ingredient is developed


Figure 1: Features of lysolecithin ingredient PERSONAL CARE April 2024


by industrialization of whole-cell enzyme technology, which allows bacteria to produce


www.personalcaremagazine.com


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