ANTI-AGEING
25 20 15 10 5 0
***p<0.005 *** ***
123
***
Immediate bounce (R1)
Resilience (R5)
Prolonged elasticity (R7)
Figure 12: Improvement in skin elasticity 2 months following Epilobium fleischeri extract treatment
fleischeri extract was applied, clinical testing showed dramatic improvements in wrinkles, elasticity, and firmness. The senolytic properties of this
sustainable, environmentally friendly botanical extract and its clinical effectiveness in holistic skin rejuvenation make Epilobium fleischeri extract one of the most exciting next-generation healthy-ageing actives. Harnessing senolytics represents a
paradigm shift in anti-ageing skincare. The Epilobium fleischeri extract leads the way in translating cutting-edge senolytic science
Image 4: Reduction of crow's feet wrinkles on a 58-year-old volunteer after 3 months following Epilobium fleischeri extract treatment
into efficacious consumer products that safely restore youthful, healthy skin by targeting fundamental ageing mechanisms at the cellular level.
PC
References 1. Scudellari M. To stay young, kill zombie cells. 2017. Nature. Vol. 550, p448–450
2. Wyles SP, Carruthers JD, Dashti P, Yu G, Yap JQ, Gingery A, Tchkonia T, Kirkland J. Cellular senescence in human skin aging: Leveraging senotherapeutics. Gerontology. 2024. Vol. 70 (1), p7–14
3. Baar MP et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell. 2017. Vol. 169, p132–147
4. Zhu ML, Zhang PM, Jiang M, Yu SW, Wang L. Myricetin induces apoptosis and autophagy by inhibiting PI3K/Akt/mTOR signalling in human colon cancer cells. BMC Complement. Med. Ther. 2020 Vol. 20(1), p209
5. Kirkland JL, Tchkonia, T. Senolytic drugs: from discovery to translation. Journal of Internal Med. 2020. Vol.288(5), p518–536
www.personalcaremagazine.com
April 2024 PERSONAL CARE
Verum vs Placebo (%)
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