88 ANTI-POLLUTION
less oily and had improved barrier function (Fig 12). Finally, these benefits were substantiated by self-assessment via a questionnaire. Indeed, the volunteers reported significantly improved skin radiance, overall skin beauty and visible skin health.
PC
References 1 Pöschl U. Atmospheric aerosols: composition, transformation, climate and health effects. Angew Chem Int Ed Engl. 2005;44(46): 7520-7540.
2 Pan TL, Wang PW, Aljuffali IA, Huang CT, Lee CW, Fang JY. The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption. J Dermatol Sci. 2015;78(1):51-60.
3 Mancebo SE, Wang SQ. Recognizing the impact of ambient air pollution on skin health. J Eur Acad Dermatol Venereol. 2015;29(12):2326-2332.
4 Kim KE, Cho D, Park HJ. Air pollution and skin diseases: Adverse effects of airborne particulate matter on various skin diseases. Life Sci. 2016;152:126-134.
5 Vierkötter A, Schikowski T, Ranft U, et al. Airborne particle exposure and extrinsic skin aging. J Invest Dermatol. 2010;130(12): 2719-2726.
6 Esser C, Bargen I, Weighardt H, Haarmann- Stemmann T, Krutmann J. Functions of the aryl hydrocarbon receptor in the skin. Semin Immunopathol. 2013;35(6):677-691.
7 Köhle C, Bock KW. Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention. Biochem Pharmacol. 2006;72(7):795-805.
8 Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol. 2003;43:309-334.
9 Henkler F, Brinkmann J, Luch A. The role of oxidative stress in carcinogenesis induced by
a 40 ** *** 30 20 0 a b 10 * * 5 3 4 ** *** *
2
-5
1
-10 Placebo 1% HerbaShield URB
0 Placebo 1% HerbaShield URB
Figure 11: A cream containing 1% active ingredient reduces skin irregularities, such as spots and freckles, and improves complexion of the skin. (A) Relative reduction of brownish and reddish skin irregularities after 4 weeks compared to placebo. Visible spots were measured instrumentally. (B) Visual scoring of skin tone, evenness, appearance and spots by a dermatologist confirmed a significant improvement of the overall skin complexion after 4 weeks. Score 3 = marked dullness/ lack of skin brightness/ unhealthy appearance; Score 2 = noticeable dullness/ low skin brightness/ somewhat low vitality. The dashed line indicates the score before treatment.
metals and xenobiotics. Cancers (Basel). 2010;2(2):376-396.
10 Hines RN, McCarver DG. The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes. J Pharmacol Exp Ther. 2002;300(2):355-360.
11 Lee JM, Li J, Johnson DA, et al. Nrf2, a multi- organ protector? FASEB J. 2005;19(9): 1061-1066.
12 Saw CL, Guo Y, Yang AY, et al. The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway. Food Chem Toxicol. 2014;72:303-311.
13 Wichtl M, Blaschek W. Teedrogen und Phytopharmaka: ein Handbuch für die Praxis. In. 6 ed: Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2016.
14 Blaschek W, Hilgenfeldt U, Holzgrabe U, Reichling J, Ruth P. In. 13 ed. Hagers
b ** ***
Enzyklopädie der Arzneistoffe und Drogen: Berlin Heidelberg: Springer-Verlag; 2015.
15 Hecht SS. Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev. 2000; 32(3-4):395-411.
16 Yuan JM, Murphy SE, Stepanov I, et al. 2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke. Cancer Prev Res (Phila). 2016;9(7):598-606.
17 Marrassini C, Acevedo C, Miño J, Ferraro G, Gorzalczany S. Evaluation of antinociceptive, antinflammatory activities and phytochemical analysis of aerial parts of Urtica urens L. Phytother Res. 2010;24(12):1807-1812.
18 Asgarpanah J, E. R. Phytochemistry and pharmacological properties of Equisetum arvense L. In. Vol 6. Journal of Medicinal Plants Research 2012:3689 - 3693.
19 Stajner D, Popović BM, Canadanović-Brunet J, Anackov G. Exploring Equisetum arvense L., Equisetum ramosissimum L. and Equisetum telmateia L. as sources of natural antioxidants. Phytother Res. 2009;23(4):546-550.
20 Ghyczy M, Vacata V. Phosphatidylcholine and Skin Hydration. In: Leyden JJ, Rawlings AV, eds. Skin Moisturization. Marcel Dekker; 2002.
20 ** * 10 10
21 Van Hoogevest P, Prusseit B, Wajda R. Phospholipids: Natural Functional Ingredients and Actives for Cosmetic Products. SOFW. 2013;139(8):9 - 14.
0 Placebo 1% HerbaShield URB 0 Placebo 1% HerbaShield URB
Figure 12: A cream containing 1% active ingredient reduces oiliness and strengthens the skin barrier. Relative reduction of the skin lipidic index (A) and transepidermal water loss (TEWL; B) after 4 weeks compared to untreated skin (before treatment). Pollutants are known to increase sebum production, giving skin an oily skin appearance. Pollutants also impair the skin’s barrier function, eventually causing dry and sensitive skin. A reduction in TEWL is indicative for a strengthened barrier. N = 21; Mean ± SEM; Student’s t- test versus untreated and between treatments; * = p <0.05; ** = p <0.01; *** = p <0.001.
PERSONAL CARE EUROPE
22 Furue M, Uchi H, Mitoma C, et al. Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor- Erythroid 2-Related Factor-2. Nutrients 2017;9(3).
23 Jung K, Richter J, Kabrodt K, Lücke IM, Schellenberg I, Herrling T. The antioxidative power AP—A new quantitative time dependent (2D) parameter for the determination of the antioxidant capacity and reactivity of different plants. Spectrochim Acta A Mol Biomol Spectrosc. 2006;63(4): 846-850.
April 2018
Reduction of SOiliness (%)
Reduction of TEWL (%)
Reduction of Skin Irregularities (%)
Skin Tone Score
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