PRESERVATIVES 163


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Korsgaard B, Bjerregaard P. The preservatives ethyl-, propyl-and butylparaben are oestrogenic in an in vivo fish assay, Pharmacology & Toxicology 2000; 86(3): 110-13.


2. Routledgea EJ, Parkera J, Odumb J, Ashbyb J, Sumptera JP. Some Alkyl Hydroxy Benzoate Preservatives (Parabens) Are Estrogenic, Toxicology and Applied Pharmacology 1998; 153(1): 12-19.


3. Kang KS, Che JH. Decreased sperm number and motile activity on the F1 offspring maternally exposed to butyl p-hydroxybenzoic acid (butyl paraben), Journal of Veterinary Medical Science 2002; 64(3): 227-35.


4. Harvey PW, Darbre P. Endocrine disrupters and human health: could oestrogenic chemicals in body care cosmetics adversely affect breast cancer incidence in women? Journal of Applied Toxicology 2004; 24(3): 167-176.


5. Du S, McLaughlin B, Pal S, Aizenman E. In Vitro Neurotoxicity of Methylisothiazolinone, a Commonly Used Industrial and Household Biocide, Proceeds via a Zinc and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent Pathway, Journal of Neuroscience 2002; 22(17): 7408–7416.


6. De Groot AC, HerxheimerA. Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis, The Lancet 1989; 8633 (333): 314-316


7. Zorrilla LM, Gibson EK, Jeffay SC. The effects of triclosan on puberty and thyroid hormones in male Wistar rats, Toxicological Sciences 2009; 107(1): 56-64.


8. Kumar V, Chakraborty A, Kural MR, Roy P. Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan, Reproductive


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 Malassezia furfur MTCC 1374  Aspergillus niger ATCC 16404  Candida albicans ATCC 10231  Pseudomonas aeruginosa ATCC 15442  Propionibacterium acnes MTCC 1951  Escherichia coli ATCC 8739  Staphylococcus aureus ATCC 6538


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Figure 2: Challenge Test of Cream with 1% GalguardNT at 6.0 pH. Toxicology 2009; 27(2): 177-185


9. Badreshia S, Marks JG. Iodopropynyl butylcarbamate, American Journal of Contact Dermatitis 2002; 13(2): 77-79.


10. Proserpio G, Cattaneo R. C & T, Edizione Italia 1996; 17(3): 11-13, 16-19.


11.Nagasawa T, Kiyosawa I, Kawase K, Suzuki T, Kawashiri A. (1974). Undecylenoyl amino acids for the treatment of skin disorders. JP 49093521 A


12. Stoltz C (1999). Synergistic cosmetic composition containing a lipoamino acid and a


glycol. FR 2771632 B1


13. Stoltz C (1998). Cosmetic formulation containing a lipoamino acid and constituents of tannin-rich plant extracts. FR 2765109 B1


14.Daniel M, Wang C, Anderson J, Lewis M (2004) Compositions and methods for preserving personal care products. US20040096528 A1


15. McDonald J, McDonald S, Lundmark L, Kabara J, Garruto J (2007). Botanical extract compositions and process for preparing same. US20070196315 A1


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