108 SKIN PROTECTION Genus Characteristic
Genus increased by stress and involved in inflammation of the skin Finegoldia
Peptoniphilus Anaerobic and potentially infectious Dialister
Anaerobic and potentially infectious Gardnerella Becomes pathogenic in association with anaerobic flora
Genus increased by stress and involved in acidification of skin pH Lactobacillus Produces lactic acid
Lactobacillus Metabolises sugars into lactic acid
Genus reduced by stress and involved in protecting the skin against radiation Deinococcus High resistance to UV
Anaerobic and potentially pathogenic for the skin
Effect of Actibiome
-30% -51% -23% -40%
-12% -16%
+400%
Effect of Placebo
-36% -47% 0
+133% -4% +45% +100%
Table 2: analysis of bacterial genus which are the more impacted by a transient period of stress, and the reversing effect of 1% Actibiome versus placebo after 1 week treatment.
potentially become pathogen for skins and activate inflammatory reactions. Then stress also increases acidophilic bacteria, and decreases genus able to resist to UV rays (Table 2). It is very interesting to correlate this new microbiota print with a clinical observation of volunteer’s skin. We indeed noticed a decrease of skin pH (- 5%) in the group of stressed volunteers as well as +64% redness and a decrease in complexion homogeneity. This highlights a direct link between skin disorders that usually appear during a period of stress and the characteristics of microbiota print of stressed skins. These first investigations demonstrate the importance of a balanced microbiota for skin protection. As skin microbiota varies with age but also with body area Codif has developed a cocktail of nutrients, Actibiome, able to promote microbiota homeostasis whatever the local ecosystem. This is a universal healthy diet for all kind of microbiota and thus for all kind of skins: carbon and nitrogen sources for bacterial growth, expolysaccharide for protection
against dessication, and minerals plus trace elements for specific metabolisms (Table 3). Tested during a week at 1% on a group
of stressed volunteers, Actibiome reverses the dysbalance induced by a temporary hectic period on microbiota print and diversity (Fig 4). Among the genus significantly impacted by stress; 65% of them are reversed by Actibiome versus only 35% with the placebo. Genus involved in pH acidification, potential inflammation and skin protection are reversed (Table 2). In the meantime, Actibiome reverses skin pH previously impacted by microbiota dysbiosis, decreases redness by 65%, improves complexion homogeneity, and makes the skin healthier and more beautiful (Fig 5).
Conclusion
Our first homemade protection is a biofilm composed of a hydrolipidic emulsion and bacteria community. The balance of both components is fragile, dependent on the other one and any disturbance could
rapidly leads to skin serious skin conditions. At the age of chronic inflammatory diseases a lot of answers could come from preserving skin’s homemade protection systems and promoting the use of natural ingredients able to work for skin health and then for skin beauty.
References 1 Pentecouteau L, Gasparotto E, Vallée R,
Morvan P-Y. Evaluation of the air pollution effects on human skin using an original 3-D model, IFSCC 2014.
2 Grabenhofer R, Weiss L. Age of Inflammation: How Health is Driving the Microbiome Market (Podcast). July 12, 2017. Cosmetics &Toiletries.
3 Querleux B, Dauchot K, Jourdain R, et al. Neural basis of sensitive skin: an fMRI study. Skin Res Technol. 2008;14(4):454-61.
4 Picardo M, Ottaviani M, Camera E, Mastrofrancesco A. Sebaceous gland lipids. Dermato-Endocrinology 2009; 1(2) 68-71.
5
http://www.mindgarden.com/documents/ PerceivedStressScale.pdf
During a period of stress After treatment with actibiome After treatment with Placebo
50 48 46 44 42 40 38 36 34 32 30
* ** * Nutritional Value Per 100g
Brown Algae Extract Sugars + Polyols
Green Micro Algae Extract Amino acid + peptides
Marine Exopolysaccharide Solution
Polysaccharide
Earth Marine Water Minerals + trace elements
Table 3: Composition of Actibiome. 20g 25g 30g 25g
PC
Complexion homogeneity
Skin’s beauty
Skin’s health
Figure 8: In vivo benefits of 1% Actibiome after 1 week treatment versus placebo on skin beauty and skin health. Volunteer’s self-evaluation using numeric scale. *p</= 0.1 Student test - **p<0.05 Student test.
PERSONAL CARE EUROPE April 2018
Scorage: 0-100 scale
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