MARINE INGREDIENTS 143 p<0.05 Student test
4% 2% 0% -2% -4% -6% -8%
2.8%
9.1% -6.3% Placebo Mean value
Figure 5: Crow’s feet wrinkles depth after treatment with Fucoreverse at 1.5%, versus placebo.
Skin surface is quantitatively assessed by Lifeviz Micro. It is a non-contact in vivo skin measurement device based on structured light projection. In conjunction with a comprehensive 3D measurement and evaluation software, the sensor enables the evaluation of wrinkle depth.
Results Efficacy on crow’s feet area after 28 days After using 1.5% anti-ageing active twice daily for 28 days, statistics show that the anti-ageing active significantly decreases the depth of crow’s feet wrinkles by 9.1% on average, versus placebo. P<0.05 Student test.
Efficacy on anti-irritant properties The study showed a significant decrease in irritations and redness as shown in Figure 5. The subjects who used the product containing the anti-ageing active had good skin tolerance whereas those who used the placebo cosmetic base had moderate tolerance with a few cases of skin irritation. These results show the use of the anti-ageing active to calm sensitive skin.
Whitening the skin
100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0%
96% 88% 81% 68% 49% 8% 83.3ppm
Fucowhite 166.7ppm
Figure 7: Tyrosinase inhibition activity. April 2018 355ppm 1.2ppm 3.7ppm Hydroquinone 11.1ppm Figure 6: Macrophotography effect of 1.5% Fucoreverse on crow’s feet wrinkles.
Fucowhite is a clinically validated skin whitening ingredient which significantly decreases skin pigmentation. Fucowhite (now referred to as ‘the skin whitening active’) is a unique purified fucoidan- phloroglucinol complex, extracted from the brown algae Ascophyllum nodosum by lixiviation in water. This unique complex of fucoidan with antioxidant polyphenol, makes it an effective and versatile ingredient for whitening applications.
Tyrosinase inhibitory activity The skin’s pigmentation results from the presence of melanin in the epidermis. This pigment is synthesised in vesicles known as melanosomes of specialised cells, melanocytes. The melanin pigment is produced using tyrosine, an essential amino acid that is submitted to a series of reactions, linked to tyrosinase, as the key enzyme in this biosynthesis, to form melanin. The enzyme tyrosinase was incubated with its substrate tyrosine. The product of this reaction (melanin) was analysed by measuring the optical density at 480 nm. The skin whitening active was an effective tyrosinase inhibitor at very low concentrations.
Lightening efficacy on Asian skin type Twenty-four Asian subjects were used in a placebo controlled study during 28 days to assess the ability of a 2% skin whitening active emulsion formulation to decrease the skin pigmentation. The colour of the skin was measured by a chromameter. This appliance makes it possible to define a luminance parameter: L, clarity from dark to pale; an individual typological angle ITA which defines the degree of pigmentation of an individual’s skin.
The results show a significant increase of skin clarity and decrease of the skin pigmentation. Statistical analysis highlights a significantly better effect using the ‘active cream’ on L parameter and ITA compared with placebo. It induces a lightening effect characterised by a significant increase in L and ITA parameters.
PC
References 1. Moon HJ, Lee SH, Ku MJ et al. Fucoidan
inhibits UVB-induced MMP-1 promoter expression and down regulation of type 1 procollagen synthesis in human skin fibroblasts, Eur J Dermatol 2009; 19(2): 129-34.
2. Yang JH. Topical application of fucoidan improves atopic dermatitis symptoms in NC/Nga mice. Phytother Res 2012; 26(12):1898:903
3. Robert C, Robert AM. Effect of L-fucose and fucose-rich oligo-and polysaccharides (FROP-s) on skin aging: penetration, skin tissue production and fibrillogenesis. Skin Res Technol. 2005; 11(1):47-52.
4. Senni K, Gueniche F, Foucault-Bertaud I et al. Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis. Arch Biochem Biophys 2006; 445(1): 56-64
5. Isnard M, Fodil-Bourahla I, Robert AM, Robert
L.Pharmacology of skin aging. Stimulation of glycosaminoglycan biosynthesis by L-fucose and fucose-rich polysaccharides, effect of in vitro aging of fibroblasts. Biomedicine & Pharmacotherapy 2004; 58: 202-204.
PERSONAL CARE EUROPE D28
% inhibition
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118 |
Page 119 |
Page 120 |
Page 121 |
Page 122 |
Page 123 |
Page 124 |
Page 125 |
Page 126 |
Page 127 |
Page 128 |
Page 129 |
Page 130 |
Page 131 |
Page 132 |
Page 133 |
Page 134 |
Page 135 |
Page 136 |
Page 137 |
Page 138 |
Page 139 |
Page 140 |
Page 141 |
Page 142 |
Page 143 |
Page 144 |
Page 145 |
Page 146 |
Page 147 |
Page 148 |
Page 149 |
Page 150 |
Page 151 |
Page 152 |
Page 153 |
Page 154 |
Page 155 |
Page 156 |
Page 157 |
Page 158 |
Page 159 |
Page 160 |
Page 161 |
Page 162 |
Page 163 |
Page 164 |
Page 165 |
Page 166 |
Page 167 |
Page 168 |
Page 169 |
Page 170 |
Page 171 |
Page 172 |
Page 173 |
Page 174 |
Page 175 |
Page 176 |
Page 177 |
Page 178 |
Page 179 |
Page 180 |
Page 181 |
Page 182 |
Page 183 |
Page 184
