SKIN PROTECTION 127
Returning to our origins through skin rewilding
Júlia Comas, Olga Laporta, Marie Ollagnier, Núria Almiñana, Raquel Delgado – Lipotec, Spain
The modernisation process that came along with the Industrial Revolution promoted a reduction in human interaction with nature. This important moment also represented a trigger in the prevalence of inflammatory skin disorders such as allergies and eczemas, suggesting a link between a reduced exposure to nature and an increase in skin sensitivity. In order to travel back in time and understand the skin characteristics of our ancestors before modernisation, a study was performed on an isolated hunter-gatherer village in the Amazon jungle, whose members did not have any previous contact with urban or modern lifestyles. The research compared their skin microbial genome to that of individuals living in the United States with a lower connection with nature and higher antimicrobial practices. Results suggested that the exposure to modern lifestyles may induce alterations in the cutaneous microbiota, such as a reduction in bacterial diversity, that could make the skin more prone to sensitivity and discomfort.1
One of the most important vital functions of the skin microbiota is its contribution to the role of the skin as a protective barrier and this can occur through different mechanisms. Through the direct competition for space and nutrients, the beneficial bacteria can cause the exclusion of potentially harmful bacteria.2 Also, the reciprocal interaction of the microbiota with keratinocytes helps enhance the innate immune response, allowing the recognition of pathogens to prevent their
0 days Abstract
Discomfort, fragility, dehydration, scaliness and redness are all characteristics of sensitive skin that is lacking an effective defense system. Individuals living in urban environments are more prone to suffer from skin sensitivity, suggesting a relationship between low exposure to nature and inflammatory disorders. The link between nature and skin health involves the skin microbiota, which has been found to be different in uncontacted populations with healthier and more protected skin. Fensebiome™ peptide helped promote a healthy microbiome similar to that of our ancestors in closer contact with nature and to reinforce the physical barrier function by improving the cell cohesion and the skin barrier protective effect on urban subjects, helping restore sensitive skin.
invasion, while promoting a maintenance of the essential skin immune tolerance.3, 4 The epidermal barrier integrity is also key
in offering skin protection. In particular, the intercellular junctions found in the stratum granulosum and the lipid barrier in the stratum corneum help protect the skin form harmful elements of the environment and provide an efficient permeability barrier against excessive loss of water and electrolytes. An impaired defensive function is observed in sensitive skin, characterised by an abnormal microbial colonisation, an impaired barrier function and an aberrant lipid organisation.5 Considering the protective role of the
microbiota, the concept of cutaneous barrier function evolved from being formed not only by the most traditional physical barrier made up of lipids and corneocytes, but also by a living ecosystem considered as the second protective shield of the skin. The recently developed Fensebiome™ peptide (INCI name: Water (Aqua), Caprylyl
7 days 0 days
Glycol, Acetyl Heptapeptide-4) is a heptaptide intended to strengthen urban exposed skin by reinforcing the double cutaneous barrier function and preventing dehydration. The efficacy of the active ingredient was evaluated through several in vitro and in vivo tests.
Favourable skin microbiome A metagenomics analysis was performed on 21 female urban volunteers (18-59 years old), who applied a cream containing 1% of a solution with Acetyl Heptapeptide-4 on the cubital fossa of one arm and a placebo cream on the other, twice a day. Several microbiome parameters were assessed after 7 days of treatment.
Diversity
The diversity of skin bacteria, which is higher in the skin of people in close contact with nature, was determined by the Shannon index, used as an indicator of skin health.
7 days
Placebo April 2018
1% of a solution with Acetyl Heptapeptide-4 Figure 1: Fluorescence microscopy images obtained from different strips before and after each treatment. PERSONAL CARE EUROPE
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