SKIN CARE 155 V1 Day 0 V1 Day 30 V2 Day 0 V2 Day 30


Figure 4: Visiopor photographs of the skin under UV light from different volunteers before and after the treatment with bicomide.


decreased after the first 15 days of treatment by 5% in respect to baseline measurements and after 30 days by 24% (p <0.05). This decrease is probably related to the enhancement of the niacinamide effect that prevented the development of new acne lesions after 30 days, whereas the initial lesions had remitted.


Clinical Evaluation: prevention of new acne lesions


The count of the acne lesions after the use of the test product reduced in all the evaluated lesions, as shown in Figure 6. As for the evaluation at the beginning of the study, 30% of the volunteers had very mild acne, 35% mild, 30% moderate and 5% of the volunteers had severe acne. At the end of the study 45% of the volunteers had very


mild acne, 25% mild acne, 30% moderate and no volunteers had severe acne (Fig 7).


Visual evaluation of the volunteers by the dermatologist Macro photographs of volunteers taken before and after the treatment by Visioface 1000D were analysed in order to evaluate the evolution of the treatment. Figure 8 shows macrophotographs of volunteers on Day 0 and Day 30, where the general improvement of the acne lesions can be observed. It is worth mentioning that at the end of the treatment 80% of the volunteers expressed their satisfaction with the treatment. The results most valued by volunteers were hydration, skin smoothing, reduced oily appearance and less pimples.


3.2 3.0 2.8 2.6 2.4 2.2 2.0


T0


Time T15


T30


Figure 5: Decreases of the average % area covered by porphyrins ± SE at different experimental times during the treatment with bicomide.


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