120 ANTI-AGEING Placebo ■ 1% Ener-GY plus■
0.027 0.026 0.025 0.024 0.023 0.022 0.021 0.020
T0 Figure 2: Skin elasticity - fatigue effect
the capability to lead mitochondrial membrane potentials to activated state. The outcome confirmed that the active
cosmetic ingredient enhanced mitochondrial energetic process, providing positive conditions for metabolism and trophic cell processes. It metabolically and energetically increased active mitochondria until 54.9% after 24 hours.
In vivo proven efficacy An instrumental placebo-controlled study enrolling 24 healthy female subjects, aged over 18 years old, was performed to evaluate the improvement of skin parameters as skin moisturization, skin elasticity (R2, R0 and R9 parameters), skin radiance and skin microbiome composition (equipment: Corneometer CM 825 (Courage+Khazaka, electronic GmbH), Cutometer MPA580 (Courage+Khazaka, electronic GmbH), spectrophotometer/ colorimeter CM-700D (Konica-Minolta) and by means of 16S rRNA analysis, respectively). The study duration was 28 days and
instrumental evaluations of the skin parameters were carried out at baseline (T0) and after 14 days (T14) and 28 days (T28) of products use (product application in the morning in half-face according to a previously defined randomization scheme). Data are expressed as mean ± SEM obtained at each monitored check for the reported parameter under analysis for the two tested products. Above the error bar, the intragroup (white asterisks) and the intergroup (gray asterisks) statistical analysis are reported: * p<0.05; ** p<0.01; *** p<0.001. The application of the active ingredient
improved the facial skin profilometry measurably, visibly and noticeably after four weeks. Compared to market reference, the tested item highlighted the following. ■ An increase of skin moisturization index, respectively by +5.6% at T14 and by +7.2% at T28. These results are statistically significant both compared to baseline at each experimental monitored time compared to baseline values (data not shown). ■ An increase of skin elasticity (R2 parameter), respectively by +2.7% at T14 and by +4.5% at T28. Obtained results are statistically significant at
PERSONAL CARE April 2023
each experimental monitored time compared to baseline values and compared to placebo cream (inter-group statistical analysis) (data not shown). ■ An improvement of skin firmness due to a decrease of R0 parameter (inversely proportional to skin firmness), respectively by 4.2% at T14 and 7.5% at T28. A decrease of this parameter indicates an improvement of skin firmness and for marketing purpose can be expressed in absolute values as an increase of skin firmness. Obtained results are statistically significant at each experimental monitored time compared to baseline values (intra-group statistical analysis) and compared to placebo cream (inter-group statistical analysis). ■ A decrease of R9 parameter (representing the tiring effects of the skin) by 6.0% at T28. The obtained result is statistically significant compared to baseline value and compared to placebo cream. A decrease of R9 parameter indicates a reduction of the tiring effects (Figure 2). Therefore, clinical studies confirmed the
ability of the tested item in preventing the signs of skin fatigue thanks to a promotion of a youthful complexion by improving skin elasticity, firmness and radiance. Further evaluations also demonstrated that it helps to maintain the physiological balance in skin microbiota composition. This study was aimed to assess the skin
microbiota composition before and after the cosmetic product use by means of an instrumental placebo-controlled study carried out on 24 female subjects. The study duration was 28 days and skin microbiota was assessed by means of 16S rRNA analysis.
Conclusion Like all organisms, the skin requires appropriate energy levels to stay active and performs its protective activity towards to a multitude of environmental challenges. Cellular energy plays an essential role in skin well-being and is related to healthy and young complexion. When skin cells lose their vigour, a loss of vitality can occur and this leads to dull and tired complexion; as a result, ageing signs are highlighted. Mitochondria are gaining interest as an important target for anti-ageing skin care
market. Skincare market is constantly looking for ingredients targeting the pro-age concept: this implies that skin will look and feel less fatigued, expressing a more radiant and rested appearance. Support to the mitochondrial biogenesis and function increases the energy level and helps to use cellular energy more efficiently. It is thus reasonable to expect that skin care products, boosting mitochondrial functions, will provide skin benefits such as oxidative defense, improved skin barrier, protection from environmental assaults, and ultimately rejuvenation of skin appearance. With the present work, we intended
to demonstrated that the mitochondrial activation exerted by a biotechnological active ingredient - Ener-GY plus - from enzymatic technology not only positively support mitochondrial biochemical pathways fights low energy levels, but also recharges the skin’s natural ecosystem. The skin looks more radiant and younger. In fact, the ingredient is able to make
fibroblast mitochondria flower again, exerting beneficial effects on the multiple signs of ageing and revealing a youthful-looking skin rejuvenation, with an increased elasticity and firmness skin effect.
References 1.
Fact.MR. Anti-Fatigue Cosmetics Market. 2022
2. Grand View Research. Anti-fatigue Cosmetics Market Size, Share & Trends Analysis Report By Product (Oil, Cream, Lotion, Serum, Gel), By Distribution Channel (Offline, Online), By Region, And Segment Forecasts, 2019 – 2025. January 2020.
3. Mintel GNPD. A year of innovation in facial skincare. 2022
4. Spinelli JB, Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nat. Cell. Biol. 2018;20(7):745- 754. doi:10.1038/s41556-018-0124-1
5. Lane RK, Hilsabeck T, Rea SL. The role of mitochondrial dysfunction in age-related diseases, Biochimica et Biophysica Acta (BBA) – Bioenergetics. Volume 1847, Issue 11, 2015
www.personalcaremagazine.com T14 Experimental time (days) **
** T28
PC
R9=R3-R0
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