86 ANTI-AGEING
butyrate at a concentration of 20 mM for 48 hours. MMP1 release was then quantified using the ELISA method (Enzyme-Linked Immunosorbent Assay). As shown in Figure 2, the Lysimachia extract
significantly reduced the release of MMP1 in senescent fibroblasts compared to cells treated with the senescence inducer alone. Specifically, MMP1 release was reduced by 68% at 0.025% and 91% at 0.05%, demonstrating the ability of the extract to significantly reduce MMP1 production under stressed conditions. In addition, the new ingredient showed a
remarkable ability to suppress the release of the pro-inflammatory cytokines IL-6 and IL-8, with reductions of 89% and 95% respectively, following exposure to the senescence inducer. These results highlight the protective effects of the Lysimachia extract against cellular stress and its potential to mitigate the adverse consequences of SASP, thereby preserving skin integrity and maintaining skin longevity.
Demonstrated efficacy on skin fatigue and firmness in vivo A double-blind, placebo-controlled study was conducted to evaluate the efficacy of the new product at a concentration of 0.25% on skin fatigue and firmness in a panel of 62 Chinese female participants aged 40-55 years. The participants were randomly divided into
two groups of 31 participants and evaluated using various instruments including the Cutometer and Indentometer, as well as consumer perception questionnaires. The study aimed to evaluate the effects of the new product on skin characteristics such as fatigue firmness.
Assessment of skin fatigue Skin fatigue, characterized by a loss of elasticity and firmness due to repeated deformation, was measured using the Cutometer, focusing specifically on the F3 parameter. This parameter serves as an effective indicator of skin elasticity and firmness, with a higher F3 value indicating youthful, firm skin, and a lower value indicating aged or fatigued skin.
■ Placebo ■ Lysimachia extract at 0.25%
D14 0
■ Placebo ■ Lysimachia extract at 0.25%
60 50 40 30 20 10 0
-10 -20
D14
Figure 3: Skin fatigue measured by cutometer After the application of Lysimachia extract,
a significant increase in the F3 parameter was observed as shown in Figure 3. The results showed a significant 36% improvement in skin fatigue after only two weeks of application, which was statistically greater than the placebo group. An improvement of the fatigue parameter was also visible at the one-month mark and stabilized after two months of consistent use, demonstrating the new product’s beneficial effects on skin fatigue.
Firmness assessment Skin firmness was measured objectively using an Indentometer, a device that applies controlled pressure to the skin surface and records the depth of the resulting indentation. This technique provides valuable data on the mechanical properties of the skin, including its resistance to applied pressure. Results showed a significant improvement in skin firmness after one month of application, with a 17% increase compared to baseline
Depth into the skin surface (indentometer) D28
D28 D56 Fatigue (Cutometer - F3) (***)/Pl (***)/D0 (***)/Pl +30% (***)/D0 +36% (*)/D0 (***)/D0 (*)/D0 +26% (**)/Pl (**)/D0
Statistics: Percentage on 29-31 volunteers, Student t test/Wilcoxon test or Mann-Whitney test (*) p<0.05 (**) p<0.01 (***) p<0.001
measurements and a 6% improvement over the placebo group, as shown in Figure 4. These clinical results highlight the new
product’s positive impact on skin firmness, providing a clinically significant improvement in skin texture and resilience.
D56
Conclusion As the beauty industry shifts to the longevity in beauty paradigm, Oximony, a new product derived from Lysimachia christinae, offers a natural-based and scientifically supported approach to preserving skin function and resilience. The results provide evidence that the extract works by modulating critical ageing biomarkers, including beta-galactosidase and p16, which are markers of cellular senescence. In addition, it reduces the release of harmful senescence-associated secretory phenotype (SASP) components, such as matrix metalloproteinases (MMPs), which degrade collagen and contribute to compromising skin structural integrity. Clinical studies have shown significant improvements in skin fatigue and firmness with its use, reinforcing its role in improving long-term skin health and contributing to overall skin wellness. In addition to these benefits, the new
-5 (*)/D0 (***)/D0 -7% -10 (***)/D0 -15
(***)/D0 -6%
(***)/D0 -20 (**)/Pl Figure 4: Skin firmness measured by indentometer PERSONAL CARE April 2025 Statistics: Percentage on 29-31 volunteers
Student t test/Wilcoxon test or Mann-Whitney test (*) p<0.05 (**) p<0.01 (***) p<0.001
(***)/D0 (*)/Pl
product also addresses the growing demand for natural-based ingredients in the cosmetics industry, making it a promising ingredient for developing skin care products that meet the modern consumer’s desire for long-lasting, healthy beauty.
References 1. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023 Jan 19;186(2):243-278
2. Franco AC, Aveleira C, Cavadas C. Skin senescence: mechanisms and impact on whole-body aging. Trends Mol Med. 2022 Feb;28(2):97-109
3. Roger L, Tomas F, Gire V. Mechanisms and Regulation of Cellular Senescence. Int J Mol Sci. 2021 Dec 6;22(23):13173
www.personalcaremagazine.com
PC
% variation vs D0
% variation vs D0
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118 |
Page 119 |
Page 120 |
Page 121 |
Page 122 |
Page 123 |
Page 124 |
Page 125 |
Page 126 |
Page 127 |
Page 128 |
Page 129 |
Page 130 |
Page 131 |
Page 132
