SUN CARE A All subjects 1 # 0.5 0.5 0.5 1 B
Lighter spot group
1 * C
Darker spot group
33
0
2% ascorbyl glucoside (N=23)
Placebo (N=23)
0
2% ascorbyl glucoside (N=13)
Placebo (N=7)
0
2% ascorbyl glucoside (N=10)
Placebo (N=16)
Figure 8: Change in lightness of age spots treated, or not treated, with ascorbyl glucoside (An increase of lightness score indicates a lighter colour of age spots). Mean + SD, *p<0.05, #p<0.1 (Unpaired t-test)
Conclusion Sunlight plays a crucial role in maintaining both physical and mental health, despite its potential to cause significant skin damage. Solar UV exposure is essential for the body’s production of vitamin D, which is vital for bone health and immune function.14
suggest that moderate sun exposure offers mental health benefits.15
Furthermore, recent studies Excessive avoidance of
sunlight due to ‘sunxiety’ may negatively impact overall well-being. As a result, consumers increasingly seek sun care products that not only protect the skin from UV exposure with effective filters but also minimize skin damage caused by UV rays. Vitamin C is an essential nutrient that the
body cannot produce, yet it plays a critical role in collagen synthesis and provides antioxidant protection against UV-induced photodamage.16 A highly stable vitamin C derivative, AA2G (Ascorbyl Glucoside), offers an advanced solution for delivering the benefits of vitamin C to the skin. While remaining highly stable within formulations, ascorbyl glucoside gradually releases vitamin C upon application as skin enzymes cleave the glucose molecule. This continuous release of vitamin C makes ascorbyl glucoside an ideal ingredient for maximizing the skin benefits of vitamin C in personal care products.
This study examined the effects of ascorbyl
glucoside on photoageing, specifically its impact on UV-induced damage to the dermis and BM structure. In vitro study revealed that ascorbyl glucoside effectively prevents UVA-induced damage to the dermis and UVB-induced damage to the BM. These results suggest that ascorbyl glucoside helps preserve the integrity of the BM and dermis, thereby reducing the risk of wrinkle formation and skin sagging. Additionally, the preclinical study demonstrated its ability to lighten the appearance of existing age spots. Collectively, these findings highlight the potential of ascorbyl glucoside to prevent and improve photoageing by targeting multiple layers of the skin. In recent years, environmental friendliness is becoming highly prioritized for personal
www.personalcaremagazine.com
care products, driven by consumers demands seeking for the well-being of future planet. Ascorbyl glucoside enzymatically
manufactured by Nagase Viita, is a naturally- derived, sustainable ingredient, that offers a holistic approach to sun care for healthier looking skin, empowering people to enjoy the benefits of sunlight with confidence.
References 1. Petty L, NBC Chicago staff. ‘Sunxiety’ a common concern among patients: dermatologist. Tip to ease your mind [Internet]. NBC Chicago (US); [Published 2024 July 22]. Available from: https://
www.nbcchicago.com/news/health/ health-wellness-science-news/sunxiety- a-common-concern-among-patients- dermatologist-tips-to-ease-your- mind/3497680/
2. Masaki H. Physiological reactions in the skin exposed to solar light. Journal of Society of Cosmetic Chemists of Japan. 2013;47(3):197- 201
3. Kumano Y, Sakamoto T, Egawa M, Iwai I, Tanaka M, Yamamoto I. In vitro and in vivo prolonged biological activities of novel vitamin C derivative, 2-O-α-d- glucopyranosyl-l-ascorbic acid (AA-2G), in cosmetic fields. Journal of Nutritional Science and Vitaminology. 1998;44(3):345- 359
4. Fisher GJ, Wang B, Cui Y, Shi M, Zhao Y, Quan T, et al. Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes. Journal of Cell Communication and Signaling. 2023;17:523-529
5. Battie C, Jitsukawa S, Bernerd F, Bino SD, Marionnet C, Verschoore M. New insights in photoaging, UVA induced damage and skin types. Experimental Dermatology. 2014;23(1):7-12
6. Taniguchi M, Arai N, Kohno K, Ushio S, Fukuda S. Anti-oxidative and anti-aging activities of 2-O-α-glucopyranosyl-L- ascorbic acid on human dermal fibroblasts.
European Journal of Pharmacology. 2012;674(2-3):126-131
7. Ryu A, Arakane K, Masunaga T, Shinmoto K, Nagano T, Hirobe M, et al. Polymerization of collagen by singlet oxygen. Journal of Society of Cosmetic Chemists of Japan. 1994;28(2):163-171
PC
8. Amano S. Basement membrane damage, a sign of skin early aging, and laminin 5, a key player in basement membrane care. Journal of Society of Cosmetic Chemists of Japan. 2001;35(1):1-7
9. Shimizu H. Textbook of Modern Dermatology. 3rd ed., Nakayama Shoten; 2018
10. Amano S. Possible involvement of basement membrane damage in skin photoaging. Journal of Investigative Dermatology Symposium Proceedings. 2009;14:2-7
11. Kishimoto Y, Saito N, Kurita K, Shimokado K, Maruyama N, Ishigami A. Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts. Biochemical and Biophysical Research Communications. 2013;430(2):579- 584
12. Marionnet C, Vinoux-Chagnoleau C, Pierrad C, Sok J, Asselineau D, Bernerd F. Morphogenesis of dermal-epidermal junction in a model of reconstructed skin: beneficial effects of vitamin C. Experimental Dermatology. 2006;15(8):625-633
13. Choi W, Yin L, Smuda C, Batzer J, Hearling VJ, Kolbe L. Molecular and histological characterization of age spots. Experimental Dermatology. 2017;26(3):242-248
14. Sultana S, Naz S, Akhtar N, Ijaz M, Huma S, Khan MS et al. From rays to protection: how sun exposure affects our skin and the importance of sunscreen. Recent Updates in Disease and Health Research. 2024;9:75-85
15. Wang J, Wei Z, Yao N, Li C, Sun L. Association between sunlight exposure and mental health: evidence from a special population without sunlight in work. Risk Management and Healthcare Policy. 2023;16:1049-1057
16. Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. Nutrients. 2017;9(8):866
April 2025 PERSONAL CARE
Change in lightness score (After - Before)
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