COVER STORY: ASHLAND ADVERTISEMENT FEATURE A
1. Ex vivo, biosy, IHC 2. In vitro, fibroblast, ICC 3. In vitro, keratinocytes, ICC 4. In vitro, qPCR, fibroblasts
+208%4
+52%***1 +120%4 +72%***1 +44%***1
COL5A2 COL3A1
COL5A1 +40%***1 COL5A3 COL18A1 +56%***1 COL7A1 COL17A1 +145%***1 COL6A1 COL6A2 +42%***1 COL6A3 +21%***2 +163%4 *** Highly significant Effect of Collapepty™ on skin collaverse™
Synergistic effect of collapeptyl on collagen I expression
Figure 2: Effect of collapeptyl on skin collaverse™ (a) and focus on synergistic effect of collapeptyl on collagen I expression (b) Thus, the computed peptides/HA
interactions with hyaluronic acid molecule. Tripeptide-1 upregulates collagen, elastin and glycosaminoglycan production in fibroblasts;2 and hexapeptide-9, is a well-known anti- aging peptide with the ability to facilitate skin regeneration and to reinforce the extracellular matrix.3,4
interaction energy was due to the self- assembled hydrogen bonding, shown in figure 1. To strengthen these interactions and boost the efficiency of collapeptyl™, a new technology was created: 2HP™ technology based on the use of a specific size of
Cream with 5% silicone ■ cream with 5% collapeptyl™ ■ Ease of spreading Skin smoothness
5 4 3 2 1
0 Skin softness Tackiness
Product Pick-up
Skin comfort Greasiness Figure 3: Evaluation of the sensorial effect of collapeptyl™ formulated at 5%
www.personalcaremagazine.com April 2025 PERSONAL CARE
Powdery AfterFeel
Skin Softness Shine Cushion feel
Playtime/ Slip
Quick
break/fresh sensation
Ease of spreading
8 6 4 2 0
Playtime/slip Tackiness
hyaluronic acid (≤ 5 kDa) added to an optimal concentration of each component and a key step during the process. To complete the design of collapeptyl™, the complex peptides/HA was integrated in cellulose gum bringing new texturing property of this unique biofunctional.
COL15A1 +188%4
Collapeptyl™ at 5%
COL1A2
COL11A1 COL12A1 COL14A1 +20%***%2
+110%4 +73%4
COL16A1 COL4A2
+41%***1 COL4A5 COL8A1 COL8A2 1 1
fibrillar collagen: COL1A2
1
fibrillar collagen: COL1A2
fibrillar collagen: COL1A2
1
fibrillar collagen: COL1A2
collaverse™ 1
1
fibrillar collagen: COL1A2
fibrillar collagen: COL1A2
8 families of collagen B
+103%4
+32%***3 +99%4 +31%***1
the skin 1
fibrillar collagen: COL1A2
1
fibrillar collagen: COL1A2
21
1
fibrillar collagen: COL1A2
Greasiness/ oiliness
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118 |
Page 119 |
Page 120 |
Page 121 |
Page 122 |
Page 123 |
Page 124 |
Page 125 |
Page 126 |
Page 127 |
Page 128 |
Page 129 |
Page 130 |
Page 131 |
Page 132
