46 ANTI-AGEING
damage. This protection is vital for maintaining cellular energy production and preventing premature ageing.
Discussion The findings from this study underscore the potential of Ilex Extract as a potent skin energizer and a healthy ageing ingredient suitable for longevity products. Its ability to enhance microcirculation and oxygenation is a key factor in its efficacy, as these processes are fundamental to maintaining healthy, vibrant skin. The vasodilatory effects of caffeine and polyphenols improve blood flow,6,7
IMPROVEMENT IN CERAMIDES AFTER 4 DAYS Untreated control
ensuring that
skin cells receive the oxygen and nutrients they need to function optimally. The increase in ceramide production and
mitochondrial protection further supports Ilex Extract’s role in promoting a youthful appearance. By strengthening the skin barrier and protecting cellular structures, the ingredient helps combat the visible signs of ageing, such as wrinkles and loss of elasticity and firmness. Rather than merely addressing the symptoms of ageing, Ilex Extract supports the skin’s natural processes, fostering resilience and vitality that contribute to healthy ageing. In the context of longevity, Ilex Extract aids in maintaining the skin’s youthful state by supporting cellular health and energy production. By protecting mitochondria and enhancing microcirculation, it ensures that skin cells remain active and efficient, which is crucial for long-term skin health. This approach aligns with the concept of healthy ageing, where the focus is on preserving the skin’s natural functions and appearance over time, rather than simply reversing the signs of ageing. Moreover, the upcycling of maté dust to
produce Ilex Extract aligns with sustainable practices, offering an environmentally friendly source of active ingredients. This approach not only reduces waste but also provides a valuable resource for the cosmetic industry. Not only the CO2
consumption but also the water footprint
of the product was assessed, a one-of-a-kind situation for cosmetic active ingredients.
Conclusion Yerbaluxe-Pearl (Ilex Extract) emerges as a promising ingredient in the cosmetic industry, offering a scientifically substantiated approach to enhancing skin vitality. Its multifaceted benefits, from improving skin oxygenation and
UNTREATED CONTROL
150 125 100 75 50 25 0
Ilex Extract 0.01% **
Untreated ■ Ilex Extract 0.01% ■
Mean + SEM; n = 10/10; **=p<0.01
Figure 7: Ilex Extract increases ceramides production. Quantitative immune fluorescent staining of ceramides in the epidermis of a skin explant 3D reconstructed epidermis shows a significant increase in ceramides deposition after 4 days compared to untreated (placebo) condition. Left panels: staining with anti-ceramides antibody, right panel: quantification. SB: Stratum basale, SC: Stratum corneum
microcirculation to protecting mitochondria, position it as a valuable addition to skincare regimens aimed at promoting a youthful and radiant appearance. It is ideal for younger buyers who value
healthy ageing and follow a holistic approach to body and skin, as well as for customers who are looking for effectiveness for a rejuvenated appearance. The combination of efficacy, sustainability, and innovation makes Ilex Extract a standout ingredient in the quest for healthier, more vibrant skin.
methylxanthines and in vitro antioxidant activity. Food Science and Technology (Campinas). 2020;40
3. Wierzejska RE, Gielecińska I. Evaluation of the Caffeine Content in Servings of Popular Coffees in Terms of Its Safe Intake-Can We Drink 3-5 Cups of Coffee per Day, as Experts Advise? Nutrients. 2024;16(15)
PC
References 1. Stücker M, Struk A, Altmeyer P, Herde M, Baumgärtl H, Lübbers DW. The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis and epidermis. J Physiol. 2002;538(Pt 3):985-94
2. Zielinski A, Alberti A, Bona E, Bortolini D, Benvenutti L, Bach F et al. A multivariate approach to differentiate yerba mate (Ilex paraguariensis) commercialized in the southern Brazil on the basis of phenolics,
UVA IRRADIATION
4. Valduga AT, Gonçalves IL, Saorin Puton BM, de Lima Hennig B, Sousa de Brito E. Anthraquinone as emerging contaminant: technological, toxicological, regulatory and analytical aspects. Toxicol Res. 2024;40(1):11-21
5. Rajkumar J, Chandan N, Lio P, Shi V. The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair. Skin Pharmacology and Physiology. 2023;36(4):174-85.
6. Herman A, Herman AP. Caffeine’s mechanisms of action and its cosmetic use. Skin Pharmacol Physiol. 2013;26(1):8-14
7. Iqbal I, Wilairatana P, Saqib F, Nasir B, Wahid M, Latif MF et al. Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review. Molecules. 2023;28(17)
UVA IRRADIATION+ILEX EXTRACT 0.1%
PINK1 staining
Figure 8: Ilex Extract protects mitochondria from UV-A radiation. Semiquantitative PINK1 staining of skin explants show a marked increase when exposed to UV-A radiation. This is reduced back to non-radiated condition when 0.1% Ilex Paraguariensis Extract was used
PERSONAL CARE April 2025
www.personalcaremagazine.com
Relative to untreated control
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