COVER STORY: ASHLAND ADVERTISEMENT FEATURE 5% collapeptyl™ application D0
Wrinkle’s depth before application ■ Wrinkle’s depth one month after 5% collapeptyl application ■ Cut
0.060 0.046 0.031 0.016 0.001 -0.013
-0.028 -0.043 -0.057 -0.072 -0.087
23
0.000
0.384
˜20 µm reduction in depth of wrinkles 0.768
1.152 1.536 1.920 Caucasian women, 53-year-old D28
15 10 5 0
-5 -10 Placebo treated group Figure 5: Wrinkles depth evaluation of eye contour after 1 month of application with 5% collapeptyl™ containing cream
cellulosic gum element with molecular complex peptides/HA. The first one, consisting in applying a mask, containing 5% of collapeptyl™ on one side of the face and a placebo mask on the other side of the face, demonstrated an instant glass-like radiant and smooth, hydrated skin after 30min and 4h of mask removal on 30 Asian volunteers (Figure 4).
The second study was long-term,
carried out on 34 volunteers divided in two homogeneous groups. Both groups applied a cream containing 5% biofunctional or its placebo for 1 month. Since D14, the skin hydration increased significantly by 272% compared to placebo with a smoother and softer skin. These effects remained after 1 month of application accompanied by an improvement in skin elasticity for the group applying collapeptyl™ cream. Likewise, after one month of applications, with the biofunctional containing cream, softens the appearance of wrinkles of the crow’s feet area but also under the eye, significantly decreased in circumference by -196% and in depth by -105% with an impact of all kinds of wrinkles (Figure 5). In summary, collapeptyl™ biofunctional helps hydrate and smooth the skin after
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30min and 4h of mask application with increasing skin glow, giving a glass skin aspect. Additionally, collapeptyl™ improves skin elasticity and hydration after 1 month of application. Besides the instrumental measurements, volunteers observed a clear reduction in appearance of wrinkles and an improvement in skin global appearance (better hydration, glow and elasticity). A game-changer in the ‘iconic’ collagen
world, collapeptyl™ helps deliver both functional and sensory benefits. Globally approved, and tested on Caucasian and Asian skin type, collapeptyl™ biofunctional blurs the line offering a rapid transformative effect, skin feel and measurables results by consumers. Easy to formulate, it is compatible with serums, gels, masks and creams. More than skincare, this is a revolution in collagen science, a breakthrough in sensorial beauty, unlocking your skin’s full potential.
References 1. Fallacara A, Baldini E, Manfredini S and Vertuani S., Hyaluronic acid in the third millennium. Polymers. 2018; 10, 701
2. Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in
Skin Regeneration. Biomed Res Int. 2015;2015:648108
3. Bauza E, Oberto G, Berghi A, Dal Farra C, Domloge N. Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. Int J Tissue React. 2004;26(3-4):105-11
4. Perrin A, Bauza E, Dal Farra C, Domloge N. Stimulating effect of collagen-like peptide on the extracellular matrix of human skin: histological studies. Int J Tissue React. 2004;26(3-4):97-104
5. Huang A, Guo G, Yu Y et al. The roles of collagen in chronic kidney disease and vascular calcification. J Mol Med. 2021; 99; 75–92
6. Theocharidis G, Connelly JT. Minor collagens of the skin with not so minor functions. J Anat. 2019 Aug;235(2):418-429
PC Collapeptyl™ effect on different kind of wrinkle
Medium wrinkles -5.2mm
Expression wrinkle
Deep wrinkles -0.83mm
Expression wrinkles -2.9mm
Expression wrinkle Medium wrinkle
Deep wrinkle 5% collapeptyl™ treated group
2.304 Section lenght (mm)
2.688
3.072
3.456
3.840
Ashland 500 Hercules Road, Wilmington, DE 19808, USA
www.ashland.com
April 2025 PERSONAL CARE
Δmm (D28-D0)
z (mm)
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