50 ANTI-POLLUTION
1000 800 600 400 200 0
Sham
Blue Light
Alpha-Tocopherol (20µM) DavosLife E3 Tocotrienols(20µM)
‒ ‒
DavosLife E3 Tocotrienols in protecting the skin barrier from PM2.5-induced damage.
Conclusion Modern pollution disrupts skin health by inducing oxidative stress, accelerating skin ageing, hyperpigmentation, and impairing the skin barrier. Our studies demonstrated that DavosLife E3 Tocotrienols protect blue-light-exposed skin cells by regulating ROS, mitigating mitochondrial damage, and reducing tyrosinase activity, effectively minimizing hyperpigmentation. Additionally, DavosLife E3 Tocotrienols protect
against air pollution-induced skin damage through their antioxidative, anti-inflammatory, and skin barrier-restorative properties. DavosLife E3 Tocotrienols are naturally
derived from non-GMO palm fruits sustainably sourced from RSPO-certified (Roundtable of Sustainable Palm Oil) plantations and produced in an RSPO-certified facility. In addition to sustainable sourcing, DavosLife E3 Tocotrienols comply with major international regulatory standards on Persistent Organic Pollutants (POPs) and are free from harmful chemical contaminants such as pesticides, industrial contaminants, and heavy metals. The Cosmetic Ingredient Review (CIR)
Expert Panel has assessed Tocotrienols and α-Tocopherol as safe for cosmetic applications. The DavosLife E3 DVL range of Tocotrienols is Halal and Kosher-certified, with attestation from ECOCERT Greenlife, ensuring compliance with COSMOS standards.
Tocopherol Alpha- Blue light (38J/cm2 + ‒ ) ‒ + PM2.5 (100µg/mL)
Figure 4: Tyrosinase activity in B16-F1 cells after blue light (BL) and treatment. Data shown are expressed as % of sham and expressed as mean ± SEM
3 and prevents photooxidation of melanin precursors on skin cells exposed to blue light emitted from digital devices. Antioxidants. 2021; 10, 400.
4. Fu H, Yen FL, Huang PH, Yang CY, Yen CH. Oleanolic acid nanofibers attenuated particulate matter-induced oxidative stress in keratinocytes. Antioxidants, 2021; 10
5. Mintel Research. Conscious Cosmetics: the rise of Clean Beauty. 18 October 2024. https://
www.mintel.com/insights/beauty-and- personal-care/conscious-cosmetics-the-rise- of-clean-beauty/
6. Neo JRE, Teo CWL, Ung YW, Yap WN. Tocotrienol-Rich Fraction Attenuates Blue Light-Induced Oxidative Stress and Melanogenesis in B16-F1 Melanocytes via Anti-Oxidative and Anti-Tyrosinase Properties. International Journal of Molecular Sciences. 2023; 24(20), 15373
7. Dijkhoff IM, Drasler B, Karakocak BB, Petri-Fink A, Valacchi G, Eeman M, Rothen-Rutishauser B. Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies. Part. Fibre Toxicol. 2020; 17 (1), 35
8. Neo JRE, Teo ZNT, Yeo JSE, Ng CKS, Teo CWL, Ung YW, Yap WN. Tocotrienols improve urban particulate matter-induced skin damages by regulating skin barrier function and ROS/ MAPK signalling pathway in keratinocytes. Atmospheric Pollution Research. 2022; 13 (10)
PC
References 1. O’Hagan JB, Khazova M, Price LL. Low-energy light bulbs, computers, tablets and the blue light hazard. Eye. 2016; 30,230–233.
2. Lorrio S, Rodriguez-Luna A, Delgado-Wicke P, Mascaraque M, Gallego M, Perez-Davo A, González S, Juarranz Á. Protective effect of the aqueous extract of deschampsia antarctica (EDAFENCE((R))) on skin cells against blue light emitted from digital devices. Int J Mol Sci. 2020, 21, 988
3. Portillo M, Mataix M, Alonso-Juarranz M, Lorrio S, Villalba M, Rodriguez-Luna A, González S. The aqueous extract of polypodium leucotomos (Fernblock((R))) regulates opsin
PERSONAL CARE April 2025 Figure 7: Effects of DavosLife E3 Tocotrienols on skin barrier function upon PM2.5 exposure
www.personalcaremagazine.com
Figure 5: Effects of DavosLife E3 Tocotrienols and alpha-tocopherol treatment on the generation of ROS upon PM2.5 induction. HaCaT cells were pre-treated with DavosLife E3 Tocotrienols (20 µM) or alpha-tocopherol (20 µM) followed by 100 µg/ml PM exposure. After 30 min post-induction, the intracellular ROS levels were determined using the fluorogenic probe DCFH-DA. The relative intensity of DCF fluorescence is shown in the bar graph
8 6 4 2 0
DavosLife E3 Tocotrienols
0
3 2 1
PM2.5 (100µg/mL)
Figure 6: Suppression of COX-2 expression by DavosLife E3 Tocotrienols in stimulated PM. Note that sham exposure did not induce the activation of the pathways. The relative protein expression levels were quantified by densitometric analysis
% Tyrosinase Activity (
W.r.t.sham)
Relative Density ratio (COX-2/β-actin)
Sham Control Alpha- tocopherol
DavosLife E3 Tocotrienols
Relative DCF Fluorescence (fold change compared to sham) Sham Control Alpha- tocopherol
DavosLife E3 Tocotrienols
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