48 ANTI-POLLUTION


A natural shield against modern pollution


Marianne Loong, Ung Yee Wei – KLK Oleo


In today’s digital age, skin exposure to modern pollution has increased due to both artificial light from digital devices and air pollution from industrial and urban activities. Blue light, a high-energy visible (HEV) light


emitted from screens and artificial lighting, is a major component of light pollution.1


Prolonged


exposure to blue light induces oxidative stress in skin cells, leading to photoageing, hyperpigmentation, inflammation, and a weakened skin barrier.2,3 Additionally, 92% of the world’s population


resides in areas where air pollution exceeds WHO’s recommended limits. Airborne pollutants generate oxidative stress, compromise the skin barrier, and aggravate conditions such as atopic dermatitis. Furthermore, they activate matrix metalloproteinases (MMPs), accelerating skin ageing and reducing elasticity.4


Natural antioxidant bioactives in skin care Since oxidative stress is strongly linked to modern pollution, skin care formulations designed to counteract these effects must incorporate antioxidant bioactives. Consumers are increasingly prioritizing natural ingredients in their beauty products, with over 40% seeking formulations based on natural components. This trend is expected to drive market


growth from USD 642 million in 2022 to USD 1,095 million by 2030.5


In response, the industry


is moving towards incorporating natural antioxidant bioactives into anti-blue light and


600 400 200 0


Sham


Blue Light


Alpha-Tocopherol (20µM) DavosLife E3 Tocotrienols(20µM)


‒ ‒


tocopherol Alpha- Blue light (38J/cm2 + ‒ ) ‒ +


Figure 1: Quantification of relative DCFDA fluorescence intensity to represent intracellular ROS. Data shown are expressed as % of sham and expressed as mean ± SEM


PERSONAL CARE April 2025


DavosLife E3 Tocotrienols


anti-pollution skin care. DavosLife E3 Tocotrienols, members of the


vitamin E family, are highly effective bioactives for these applications. They possess potent antioxidant and anti-inflammatory properties. Due to their three unsaturated double bonds, tocotrienols exhibit superior tissue penetration, enhancing their efficacy in protecting and rejuvenating skin.


A natural solution to combat blue light exposure Excessive blue light exposure leads to an accumulation of reactive oxygen species (ROS), resulting in mitochondrial damage and cell death in skin. We investigated the protective effects


of DavosLife E3 Tocotrienols against blue light exposure in murine melanoma B16-F1 cells.6


The study utilized a tocotrienol-rich


fraction (TRF), containing four tocotrienol isomers (α-, β-, γ-, and δ-tocotrienols) and alpha-tocopherol. Given their antioxidant properties, we hypothesized that DavosLife E3 Tocotrienols could mitigate ROS accumulation, thereby reducing cell death and hyperpigmentation. To examine oxidative stress in B16-F1


cells exposed to blue light, we used the 2’,7’-dichlorofluorescin diacetate (DCFDA) fluorescent probe and captured images using fluorescence microscopy. A stronger fluorescence signal was observed in cells irradiated with blue light compared to the sham group (negative control group). However, treatment with alpha-tocopherol and tocotrienols reduced this signal, with tocotrienols demonstrating a greater antioxidative effect compared to alpha- tocopherol (Figure 1).


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% Relative


Fluorescence Intensity (W.r.t.sham)


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