114 NATURAL INGREDIENTS
3. Repair and regeneration phase (recovery phase) Following resolution, the repair phase aims to restore normal tissue function. It involves cell proliferation, new blood vessel formation, and fibroblast activation for collagen synthesis. This step repairs the damaged tissue barrier and strengthens the affected areas. Inflammation is essential for defence, but
precise regulation between pro-inflammatory and anti-inflammatory mediators is necessary to prevent permanent damage or chronic inflammation. Once the initial cause is treated, the resolution phase must be well-orchestrated to ensure effective healing.
A model of sustainable technology This innovation is the result of a patented, virtuous, and sustainable technology. Microalgae cultivation requires precise expertise for each species, optimizing the production of highly concentrated molecules. An important phase in production is the use of green energy, produced by a closed-circuit waste recycling system where purified CO2
for microalgae growth, ensuring the lowest possible carbon footprint. This eco-friendly process makes our
greenhouse an advanced, sustainable production unit, fully energy-independent. The high-value molecules obtained include long-chain omega-3 (EPA, DHA), and omega-6, lipids, proteins, antioxidants, vitamins, and pigments.
Composition and innovation Kalahari melon seed oil Often called the liquid gold of South Africa,Kalahari melon seed oil is a precious oil with multiple skin benefits. Extracted from desert melon seeds, it is rich in omega-6 and omega-9 fatty acids, as well as antioxidants and phytosterols. This oil strengthens the skin barrier, boosts hydration, and improves skin suppleness. Beyond nourishment, it has anti- inflammatory and reparative properties, helping to regulate inflammation by reducing pro- inflammatory mediators during the initial phase. During the resolution phase, it stimulates the
production of resolution mediators, accelerating skin repair and tissue regeneration. This regulatory effect makes it a key ingredient for
160 120 80 40 0
EGF 10 ng/mL ctrl +
0% ctrl - 0.10% POSITIVE CONTROL (EGF 10ng/mL) T0 POSITIVE CONTROL (EGF 10ng/mL) 24H
NATURA-TEC SEAWONDER AT 0.5% OF USE is reused as a key metabolic element
NATURA-TEC SEAWONDER AT 1% OF USE
Figure 1: In vitro testing results comparing different concentrations of SeaWonder with negative (Ctrl -) and positive (Ctrl +) controls
wound healing and fibroblast migration, crucial for connective tissue reconstruction.
An innovative microalgae The selection of a specific microalga species from the Nannochloropsis family, cultivated
Relative wound healing closure 29.5% 14.4%
under controlled stress conditions, ensures a high-quality extract rich in plant-derived cholesterol. This microalga is the first significant plant- based source of cholesterol, a key component of skin barrier function. It also contains long- chain omega-3 (EPA), which plays a vital role in the production of resolution mediators essential for wound healing.
Natura -Tec SeaWonder concentrations (%) 1%
0.50%
Figure 2: In vitro testing results comparing different concentrations of SeaWonder with negative (Ctrl -) and positive (Ctrl +) controls
PERSONAL CARE April 2025
Properties and benefits Wound healing – in vitro evaluation In vitro testing has demonstrated that the active ingredient significantly accelerates the wound healing process, providing a tangible improvement in skin regeneration. To assess its effectiveness, different concentrations were tested: 0.1%, 0.5%, and 1%. The test was validated using a positive
control (ctrl +), EGF E9644, an Epidermal Growth Factor (EGF) at a concentration of 10 ng/mL, serving as a benchmark for cell migration stimulation. These results were also compared to a negative control (ctrl -), representing natural wound healing without the addition of the active ingredient. This
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Relative wound closure vs control (%)
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