SUN CARE


31


Gelation


Control -UVA


0


10 +UVA Figure 4: UVA-induced gelation of collagen solution with or without ascorbyl glucoside


immunostaining compared to a non-treated sample (Figure 6A). Further, 2% ascorbyl glucoside-treated samples showed an increase of type IV collagen expression (Figure 6B). These data suggest that ascorbyl glucoside


can positively affect both the expression and deposition of type IV collagen, which enhances the structural integrity of the BM. Secondly, the expression level of type IV


collagen in UVB-irradiated NHEK was evaluated to examine whether ascorbyl glucoside can prevent photo-induced damage to the structure of the BM. At the same time, to further assess UVB damage, the level of type IV collagen degrading enzyme (MMP-9: Matrix metalloproteinase-9) was evaluated. In the study, NHEK were incubated overnight with 5 mmol/L ascorbyl glucoside, exposed to


5


1


Ascorbyl glucoside (mmoI/L


Figure 5: Molecular structure around basement membrane


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April 2025 PERSONAL CARE


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