20 ADVERTISEMENT FEATURE
COVER STORY: ASHLAND
The future of collagen innovation
Collagen is the structural backbone of the skin, ensuring its strength, resilience, and youthful appearance. However, with age and environmental stressors, collagen synthesis declines, leading to visible signs of aging such as wrinkles and loss of firmness. While the cosmetics industry has long sought to replenish collagen, traditional approaches often fall short of delivering truly biomimetic, effective, and sensorially appealing solutions. Until now. Discover collapeptyl™ biofunctional and
the Collaverse™—the intricate ecosystem of 28 diverse and interconnected collagens that maintain skin integrity and youth. Inspired by the natural ability of dermal hyaluronic acid molecules to house, protect and distribute skin peptides, collapeptyl™ biofunctional is the next generation hyalupeptide hybrid, a vegan suitable, 99.7% natural (according to ISO 16128) collagen peptide solution designed to work in harmony with the skin, unlocking its full potential. Why? Because Ashland’s team of R&D solvers have harnessed the science of molecular modeling to optimize the binding affinity of two powerful anti-aging peptides to a short-chain hyaluronic acid molecule. By mimicking 20 key collagen sequences,
this innovative active offers dual-action power: an instant glass-like glow with a velvet-smooth feel, combined with long-lasting biological effects—correcting
April 2025 GLOBAL PERSONAL CARE INGREDIENTS ● FORMULATION ● MANUFACTURE
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experience with a velvet, smooth after-feel that elevates every formulation. This article delves into the science behind collapeptyl™, exploring how advanced bioengineering, peptide and molecular modeling innovation, are shaping the future of collagen innovation in skin care. Now with collapeptyl™ biofunctional,
you too can transform your formulations, by bridging science, sensoriality, and efficacy like never before.
Product development panel discussion: Lucas Meyer, Evonik Gattefossé, Provital
Skin care Sun care Hair care Testing
Plus: in-cosmetics Global Formulation Lab preview
appearance of expression wrinkles in just 4 hours and deep wrinkles in 1 month. Powered by groundbreaking patent- pending 2HP™ technology (Hyaluronic Hybrid Peptide), this unique texturactive™ ingredient is not only a performance-driven collagen booster delivering exceptional and rapid visible benefits but also a sensorial
How AI enabled the design of the perfect matrix-mimetic 3D hybrid As unlikely as it may seem, the composition of collapeptyl™ biofunctional was determined by the artificial intelligence. The first identified component was hydrolyzed hyaluronic acid. Hyaluronic acid, key molecule of skin aging, is a natural glycosaminoglycan, composed of repeating polymeric disaccharides of glucuronic acid and N-acetylglucosamine. Due to its unique physico-chemical properties, collapeptyl™ biofunctional offers a wide configuration and shapes of HA each dependent on different parameters including the size and the pH, allowing different an even wider range of applications including drug delivery systems.1 Through molecular modeling, two
peptides, known for their anti-aging efficiency, were selected for their strong
Hexapeptider-9 (CollaxyTM
) Tripeptide-1
Hydrolyzed sodium hyaluronate (HA)
Dotted lines show hydrogen bonds Figure 1: Self-assembled interaction shown by molecular modeling science PERSONAL CARE April 2025
www.personalcaremagazine.com
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