NATURAL INGREDIENTS
79
30
20 * 10 * * 0 Control AC Vehicle Jojoba PO
Figure 3: The impact of Jojoba oil on HSV-1 infected cells in comparison to Control, Acyclovir (AC), Vehicle (Mock) and Petroleum Oil (PO)
Jojoba oil as an active ingredient While mostly used in cosmetics applications, jojoba oil has many benefits as an active ingredient. It is well-known as an anti- inflammatory ingredient, anti-microbial and anti-viral agent, and for its ability to increase cutaneous wound healing, inhibit acne and psoriasis manifestations, and reduce oxidative stress. Two recent peer-reviewed studies reveal
new understanding of the importance of jojoba oil as an anti-viral and an anti-ageing agent.
Jojoba oil as an anti-herpes agent
A recent study conducted by a group of Israeli researchers from the Gilat Research Centre, the Dead-Sea and Arava Science Centre, and the Eilat Campus of the Ben-Gurion University, and that was published in Molecules has shown, with high statistical significance, the impact of jojoba oil in the prevention and treatment of Herpes Simplex 1 (HSV-1) virus infection.1 The researchers evaluated Jojoba oil
made of four different varieties of jojoba. The results revealed a similar anti-viral effect for all four varieties, with high potency (EC50 of 0.96 ± 0.4 µg/mL) that blocked HSV-1 plaque formation. The antiviral activity of the oil was also confirmed by real-time PCR, as well as viral protein expression by immunohistochemical staining. Another interesting result,
demonstrated that the observed effects were independent of the presence of simmondsin, which is occasionally associated with the medicinal attributes of jojoba oil, and that jojoba oil presence was required to gain protection against HSV-1 infection. The results were compared with
other potential treatment agents including approved commercial anti- herpes drugs, as seen in Figure 3. Quantification of HSV-1 infection
by fluorescent immunohistochemical analysis gave additional confidence to the
www.personalcaremagazine.com
150 125 100 75 50 25 0
*
*
Control
Vehicle
Jojoba
AC
Figure 4: Viral protein quantification. DAPI (blue) was used as counterstaining. Levels of Control, Vehicle (Mock), Jojoba and Acyclovir (AC) were compared
effectiveness of jojoba oil in preventing the viral activity. Fluorescent DNA Stain (DAPI)
counterstaining was performed and the quantification of the analysis, further demonstrating jojoba wax efficacy (Figure 4). In summary, the results demonstrate
potential high efficacy for the use of jojoba oil for the treatment of HSV-1, and support the use of jojoba oil as an agent that could protect and treat HSV-1 skin infections. In terms of applications, based on the
results above, it would make much sense using jojoba oil in lip care products like lip balm and lip sticks.
Jojoba as a collagen remodelling/ skin rejuvenation agent The same group of researchers - in cooperation with the Faculty of Agriculture at the Hebrew University of Jerusalem and the Department of Plastic Surgery at the Soroka University Medical Centre - has recently concluded another breakthrough study that demonstrates the effect of jojoba oil on skin
collagen and hyaluronic acid synthesis and the anti-inflammatory activity of the oil.2 The study, which was supported by Jojoba
Valley, a producer of jojoba oil based in Israel, was conducted as an ex vivo study on human skin organ culture. The safety was evaluated by various means including histology (H&E) and by electron microscope. Efficacy of the reduction of inflammation
level was evaluated by measurement of pro- inflammatory cytokines levels, while efficacy was evaluated by the measurement of the levels of collagen and hyaluronic acid, as well as the levels of TGF-β3 expression and mRNA Collagen levels. Evaluation of skin morphology indicated
the complete safety of the oil, while in terms of efficacy, a reduction of 30% in the inflammation level was measured following topical application of the pure jojoba oil. This effect was doubled when jojoba oil
was integrated into a formulation based on Triton X-100 (an emulsifier that increases the oil bioavailability), and its efficacy was equal to the activity of dexamethasone, a commercial anti-inflammatory corticosteroid. In addition, a significant twofold increase
was detected in the synthesis of both pro- collagen and hyaluronic acid, compared to the control lesion (Figure 5). The importance of the results of the study can be evaluated in the following aspects. ■ The study has shown that addition of an Emulsifier to the oil increases its bioavailability and doubles the Anti- Inflammatory effect of the oil. This can be relevant for future studies as well as commercial uses. ■ The study shows the effect of Jojoba oil on the remodelling mechanism of collagen and hyaluronic acid in the
cells, as well as enhanced content of Extracellular Matrix components. ■ The fact that this study was done on Human skin, with a high correlation to
clinical observations, strengthens the existing knowledge on the medicinal properties of the oil. ■ The study shows again the safety of jojoba
April 2025 PERSONAL CARE
Plaques/well
(Florescent percent of infected control)
Infection
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118 |
Page 119 |
Page 120 |
Page 121 |
Page 122 |
Page 123 |
Page 124 |
Page 125 |
Page 126 |
Page 127 |
Page 128 |
Page 129 |
Page 130 |
Page 131 |
Page 132
