EYE AREA CARE NON-TREATED + MGO PLACEBO + MGO 1% IPEPTIDE + MGO
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Figure 3: Effect of acetyl hexapeptide-8 on formation of AGEs on human skin explants, by measuring CML (stained in pink). Note - Explants were treated with placebo or acetyl hexapeptide-8 on Days 0, 1, 4, 6 and 8, followed by treatment with MGO on Days 6 and 8 to induce glycation
due to lack of sleep, while preventing the formation of dark circles (Figure 4). The impact of acetyl hexapeptide-8 on skin
integrity and sagging has been analysed in a unique in vivo study looking at eye opening. A panel of 24 female volunteers aged 50-64 applied a cream with 3% active ingredient (0.0015% acetyl hexapeptide-8) around one eye and a placebo around the other, twice daily for 28 days. An increase of up to 43% in eye- awakening was seen after 28 days (Figure 5). The volunteers from both studies also
completed a self-assessment on their perceived fatigue levels and appearance throughout the testing. 73% of the participants expressed they “felt like they had slept all night”, while 69% agreed that the active peptide “fights the signs of fatigue”.
Meiview High-efficacy like peptides are a popular choice among consumers and are often included in cosmetic formulations. However, there are other considerations, such as naturality, that must be taken into consideration. Meiview, hereafter Bacillus ferment, is a
naturally derived ingredient, originally obtained from the waters of Ses Salines d’Es Trenc in Mallorca, Spain. It is derived from an extremophile microorganism that lives symbiotically with one of the most salt-tolerant halophilic plants. These conditions confer unique properties, with numerous proven benefits to the eye contour area.9 Several factors, including hereditary
components, exposure to pollutants, sleep deprivation and diet, can all lead to skin thinning and a loss of cell-to-cell adhesion in the skin surrounding the eyes. These factors also affect
Figure 4: Reduction of dark circles in Volunteer 3, Days 0 & 7
microcirculation by increasing the permeability of blood vessels, resulting in liquid accumulation and under-eye bags, as well as increasing the accumulation of pigmented products, which are responsible for dark circles.10,11 Bacillus ferment has been shown to help
prevent these effects through its broad spectrum of action.9
One of its key benefits is reinforcing
skin integrity, strength and thickness, by regulating the expression and production of relevant genes and proteins. Firstly, it was found that the active
ingredient at 2% (0.01% Bacillus ferment), upregulates the ELN gene which produces elastin, and also downregulates the MMP-1 gene, which codes for matrix metalloprotease (MMP)-1, an enzyme involved in the degradation of extracellular matrix proteins including collagen. In vitro results showed a 19% reduction of MMP-1 activity compared to the untreated control. In tubo results also showed an increase in
the expression of the plakoglobin gene, which supports keratinocyte cell to cell adhesion.
This is supported by the ex vivo results, which showed a 13% increase in collagen I production after using a cream containing 1% active ingredient (0.005% Bacillus ferment) for seven days. Epidermal thickness also increased by 14% in the same time frame (Figure 6). By controlling these factors, the skin is
replenished with improved elasticity, firmness and strength, all of which help to reduce signs of ageing and puffiness in the eye area. In order to confirm this, an in vivo study in 20 male volunteers aged 35-65 was conducted. Volunteers applied a cream with 3% active
ingredient (0.015% Bacillus ferment) around one eye and a placebo around the other, twice daily for 28 days. The study showed up to 38% reduction in wrinkle depth, with a reduction of 16.3% vs. placebo on average. Eye bag volume was also reduced by up to 28%, with 80% of volunteers responding positively to the product. The average reduction was 11.9% (Figure 7). Reduction in eye bags is also a result of
reduced fluid accumulation in the eye area. In tubo tests have shown that Bacillus ferment is
Figure 5: Increase in eye opening on Volunteer 12, Days 0 & 28
www.personalcaremagazine.com April 2022 PERSONAL CARE
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