COVER STORY: ASHLAND ADVERTISEMENT FEATURE
peptides, essential minerals, organic acids, active polyphenols and small RNAs.
Caressense™ biofunctional is inspired by the ‘Science of love’ The development of Caressense™ started from the observation that people in love, no matter their age, live longer, are in better health, happier and less stressed, with more beautiful skin1
. Scientific studies have
described how love has effects not only on our psychology but also on our biology, with the release of the wellness and anti- ageing molecules, dopamine, serotonin and oxytocin. The latter is described as the ‘feel-good
molecule’ and the ‘love molecule’. It is involved in human connection, social interactions, parental care, romantic attachment and love, and also has anti-ageing properties2-4
. Love can also impact the biology of skin. Very
recent dermatological research has shown that high oxytocin levels produced by the body are correlated with more youthful-looking skin5
.
New link evidenced between skin touch and molecule of love Human touch is critical for health and well- being. Skin-to-skin contact is vital, not only for mental and emotional health but physical health too. Human touch has many benefits: it helps calm the nervous system, reduce the stress hormone cortisol, lower blood pressure and heart rate. Piezo1 and Piezo2, the mechanically activated ion channels whose discovery in the skin recently earned a Nobel Prize, represent an entirely novel class of channels functioning as touch sensors. Ashland scientists have provided new insights on skin’s oxytocin production and its decrease with aging and lifestyle stress. For the first time, researchers have highlighted the decrease of Piezo1 with age and have pointed out that a decline mimicked via Piezo1 blockage was associated with oxytocin decrease in vitro Indeed, their research revealed that oxytocin can be produced in the skin upon the activation
Control
160 140 120 100 80 60 40 20 0
+ CaressenseTM Figure 2: Caressense™ biofunctional
of the Piezo1 mechanosensor. Blocking Piezo1 in vitro by using a specific selective antagonist molecule called Doooku1 not only leads to alteration of skin morphology and skin damage, but also disrupts the expression of oxytocin (Figure 1a-b). Concomitantly, blocking Piezo1 is associated with e-cadherin loss (Figure 1c). E-cadherin is a key intercellular adhesion molecule of the epidermis with anti-sagging potential, ensuring normal tissue architecture and ‘social communication’ between cells6
.
Mimicking caring touch for well-being and well-ageing Caressense™ biofunctional was evaluated on human skin biopsies maintained in organotypic culture and proved efficient at increasing oxytocin expression level in the skin ex vivo (Figure 1b), thus mimicking the induction of oxytocin release inside the skin which can be obtained through affectionate touch and the activation of the mechanosensory system. At the same time, Caressense™ biofunctional
was capable of counteracting skin damage and e-cadherin loss induced by Piezo1 blockage (Figure 1a & c). Finally, Piezo1 decline was reproduced in vitro and Caressense™ biofunctional efficiently reversed it (Figure 2).
+40%***
7
Beneficial skin innate immunity is reliant on the Piezo1-oxytocin axis Molecules produced locally in the skin are the support of innate immunity and participate to skin barrier function and human health. Viperin is a multi- functional antiviral molecule which is part of our innate immune defence. Caressense™ biofunctional was evaluated for its ability to positively modulate the immune defence and was found to increase viperin expression level in human epidermal keratinocytes in culture (Figure 3).
Conclusion Caressense™ biofunctional has been
clinically proven to improve emotional well-being, defy signs of ageing, limit tissue sagging and provide a luminous skin tone when formulated at 2% in a cream. It mitigates the impact of lifestyles and age-induced decrease of the feel-good molecule oxytocin and Piezo1 mechanosensors of touch. This innovative bioactive represents a new
strategy in the field of well-ageing cosmetic, emphasising the emotional beauty approach with a new trend, ‘love beauty’. A message of inner beauty is delivered to consumers with Caressense™ biofunctional: love your skin, love yourself and you will age gracefully, and you will feel just beautiful and good about yourself.
References 1. Robles TF, Brooks KP, Kane HS, Schetter CD. Attachment, skin deep? Relationships between adult attachment and skin barrier recovery. Int. J. Psychophysiol. 2013 Jun;88(3):241-52
2. Schneiderman I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin during the initial stages of romantic attachment: relations to couples’ interactive reciprocity. Psychoneuroendocrinology. 2012 Aug;37(8):1277-85.
3. Feldman R. The neurobiology of human attachments. Trends Cogn. Sci. 2017 Feb;21(2):80-99.
4. Benameur T, Panaro MA, Porro C. The anti- ageing role of oxytocin. Neural Regen. Res. 2021 Dec;16(12):2413-2414. doi: 10.4103/1673- 5374.313030. PMID: 33907023; PMCID: PMC8374585.
5. Hayre N. Oxytocin levels inversely correlate with skin age score & solar damage. J. Drugs Dermatol. 2020 Dec 1;19(12):1146-1148
6. Walker DC, Georgopoulos NT, Southgate J. Anti-social cells: Predicting the influence of E-cadherin loss on the growth of epithelial cell populations. J. Theor. Biol. 2010 Feb 7;262(3):425-40
PC
Control
+ Caressense™ Figure 3: Viperin expression level in human epidermal keratinocytes: Caressense™ biofunctional vs. control
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April 2022 PERSONAL CARE
Intensity/cell area (% of control)
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