ANTI-AGEING 51 Anti UV-spots effect Placebo ■ 2% Snow algae active ■ 6 5 4 3 2 1 0 * p<0.05


Figure 7: Anti-UV spots effect of snow algae active This difference was statistically significant,


and it can also be appreciated in exemplificatory pictures. By preventing the increase in senescent cells in vivo, snow algae active maintains a healthier cellular environment on the volunteers’ skin.


During the previously described clinical study, high-definition photographs were taken both before and after treatment using the VISIA-CR system and a UV lamp. In these photographs, the area of UV spots was measured. These pigmented areas are induced by extensive exposure to the sun’s UV rays and are a clear sign of photoageing. Given that the study was performed during the


summer, the UV spots area generally increased during the 28 days of the study duration. However, for the volunteers who applied the snow algae active, the area increase was significantly less than it was for the placebo-treated group (Figure 7). Therefore, snow algae active is able to reduce the UV spots area and thus prevent photoageing. In another placebo-controlled clinical study


performed during wintertime, transepidermal water loss (TEWL) was measured before and after


Reduction in TEWL 4


2 0 -2 -4 Figure 8: Snow algae active reduces TEWL and has a moisturizing effect www.personalcaremagazine.com April 2026 PERSONAL CARE MAGAZINE The images were taken under UV lamp exposure * Before After 28 days


treatment on the face (cheeks) using a tewameter. Winter weather conditions led to an increased loss of water by the skin, as shown with the placebo. However, snow algae active was shown to


counteract this effect and even reduce TEWL (Figure 8). Therefore, even under challenging conditions, snow algae active is able to reinforce the skin barrier. Finally, results showed the capacity of snow


algae active to increase skin hydration after just two weeks of treatment. The skin hydration was significantly increased by almost 10% compared to the placebo and by almost 25% compared to untreated (Figure 8), and this moisturizing effect was observed in 100% of the subjects.


Conclusion The extract of the highly resilient snow algae provides an excellent ingredient for skin applications. By targeting seven hallmarks of ageing, snow algae active reduces biological age in skin cells, protects the skin from senescence and brings back the cells’ proteomic profile to a young state.


In vivo, while preventing senescence in sun-


exposed skin, it also hindered the formation of UV spots. In summary, snow algae active turns back the epigenetic clock and thereby rejuvenates the skin.


References 1. Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115


2. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The Hallmarks of Aging. Cell. 2013;153(6):1194-217


3. Kroemer G, Maier AB, Cuervo AM, Gladyshev VN, Ferrucci L, Gorbunova V, et al. From geroscience to precision geromedicine: Understanding and managing aging. Cell. 2025;188(8):2043-62


4. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023;186(2): 243-78.


5. Hoham RW, Remias D. Snow and Glacial Algae: A Review(1). J Phycol. 2020;56(2):264-82


Moisturizing effect Placebo ■ 3% Snow algae active ■


30 25 20 15 10 5 0


Placebo ■ 2% Snow algae active ■ * *


PCM


*


* p<0.05


Change in TEWL compared to initial conditions in %


UV spots area variation compared to initial conditions in %


Increase in skin hydration compared to initial conditions and to untreated in %


2% Snow algae active Placebo


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