50


ANTI-AGEING


Figure 5: Snow algae extract preserves mitochondrial activity and genomic stability


regeneration and latent inflammation in the skin and, therefore, the appearance of wrinkles over time.


The effect of snow algae extract in preventing


senescence was investigated by measuring beta-galactosidase activity. Beta-galactosidase is widely used in molecular biology as a reporter enzyme due to its activity having been shown to correlate with cellular senescence. In this instance, the effect of 0.1% snow


algae extract on beta-galactosidase activity was evaluated on human dermal fibroblasts. Treatment with snow algae extract resulted in a reduction of beta-galactosidase activity by 37%, which demonstrates anti-senescence activity (Figure 4). This shows that snow algae active can delay cellular ageing by preventing senescence, an important hallmark of ageing. The effect of snow algae extract on two other


hallmarks of ageing, mitochondrial dysfunction and genomic instability, was evaluated in another study, where primary human keratinocytes were treated either with or without 0.0625% snow algae extract in a pro-ageing medium and protein expression was analysed through proteomics. Snow algae extract had a corrective effect on


the protein expression changes that were induced by the ageing medium. More specifically, snow algae extract preserved mitochondrial activity by reducing the alterations in the expression of proteins involved in energy metabolism, electron transport, mitochondrial DNA maintenance, and antioxidant and stress responses (Figure 5). Moreover, snow algae extract likely preserved


genomic stability, as observed by the DNA repair protein levels being closer to young cells. Therefore, snow algae active has the potential to restore the skin to a more youthful proteomic profile


Decrease in senescent cells Placebo ■ 2% Snow algae active ■


25 * 20 15 10 5 0 5 * p<0.05 Figure 6: Snow algae extract prevents cellular senescence in vivo PERSONAL CARE MAGAZINE April 2026 www.personalcaremagazine.com * Before The hallmarks of ageing manifest themselves


as measurable phenotypes that can be clinically observed on the skin. For example, it has recently become possible to detect and quantify senescent cells in vivo, directly in the patients’ skin. These cells can be distinguished from normal


cells by their altered morphology, which becomes larger and flatter. Treatment with 2% snow algae active had a positive effect on the number of senescent cells in the volunteers’ skin. In fact, given that the study took place in Portugal during summertime, the number of senescent cells increased on the volunteers’ skin, which was likely due to sun damage. However, the ratio of senescent versus normal


cells decreased by 1.5% compared to initial conditions in areas treated by the snow algae active, while it increased by 19.3% in areas treated by the placebo (Figure 6).


After 28 days Normal cells ■ Senescent cells ■


Senescent cells relative to normal cells compared to initial conditions in %


2% Snow algae active


Placebo


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