106 TRENDING TECHNOLOGIES
and masks targeting wrinkles, loss of firmness, and overall skin revitalization can leverage LPS’s ability to support collagen and elastin promotion as well as cellular autophagy. ■ Sensitive and atopic skin products: The soothing and immune-supporting properties of LPS make it highly suitable for products designed for sensitive, reactive, or atopic skin. ■ Barrier repair products: Lotions, balms, and creams targeting compromised skin barriers, whether from environmental stress, harsh treatments, or dermatological conditions, can significantly benefit from LPS’s barrier-enhancing effects. ■ Hydrating and plumping formulations: Products focused on deep hydration and improving skin plumpness can utilize LPS to boost endogenous hyaluronic acid synthesis. ■ Post-procedure skin care: Due to its properties, LPS can be incorporated into products for post- aesthetic procedure recovery. ■ General daily skin care: In everyday skin care, LPS can contribute to overall skin resilience, maintaining optimal skin immunity and health.
Emerging potential for LPS in hair care While the primary focus of LPS research and application for cosmetic use has been on skin care, its properties suggest potential for hair care applications as well. In a mouse experiment,13
either orally or topically following the shaving of the back hair. After two weeks, mice treated with LPS showed faster hair regrowth compared to untreated controls. Although the effect was less pronounced
than that of minoxidil, the findings confirmed a significant improvement over no treatment. Hair growth is associated with blood flow and hormones. The observed effects of LPS were linked to increased expression of key genes involved in these processes. Specifically, LPS elevated levels of FGF7, a factor associated with hair follicle proliferation, and VEGF, which promotes blood flow in hair papilla cells.13 These results suggest that LPS may support
LPS (-)
Fibroblast proliferation and hyaluronic acid synthesis Fibroblast proliferation promotion
1% LPS raw material/Mϕ ■ DW ■ 1% placenta extract/Mϕ ■ 1% Placenta extract/direct ■
1.0 0.8 0.6 0.4 0.2 0
Proliferation rate of fibroblasts fed cultures of macrophages stimulated with LPS.
Promotes hyaluronic acid production in fibroblasts
Hyaluronan synthesis in fibroblasts fed macrophage culture medium stimulated with LPS
2.500 2.000 1.500 1.000 500 0
Control (DW) Day 0 Day 1 Day 2 Day 3
Figure 6: THP-1 macrophages stimulated with 0.1% LPS promoted hyaluronic acid production in fibroblasts, showing over a twofold increase vs. control in vitro
hair growth by enhancing both cellular activity and vascular supply in the scalp environment.
LPS was administered
Safety, purity, and sustainable sourcing of cosmetic-grade LPS The safety profile of cosmetic-grade LPS is paramount. The LPS used in personal care products, such as that provided by Macrophi Inc., undergoes rigorous purification processes to ensure it is highly safe and effective for topical application. Unlike the LPS from pathogenic bacteria,
which can trigger systemic inflammatory responses, the specific type and purification of LPS utilized in cosmetics are designed to exert beneficial Immune-supporting activity without adverse reactions. Its natural origin, derived from bacteria symbiotic with plants, aligns with the growing consumer demand for naturally derived and sustainably sourced ingredients. This emphasis on natural sourcing and safety
underscores its suitability as a leading active ingredient in modern cosmetic formulations.
LPS (+)
Conclusion Lipopolysaccharides represent a novel approach in cosmetic ingredient science, targeting skin health beyond surface-level effects. LPS supports key skin functions such as barrier reinforcement, hydration, and epidermal renewal. As consumers increasingly seek scientifically
backed solutions to maintain skin resilience, this engagement of innate immune pathways positions LPS as a leading example of immune-supporting cosmetic actives. Its unique combination of biological activity and natural origin makes it a strong candidate for advanced personal care formulations that aim to maintain healthy skin function. Macrophi Inc. continues to be a key provider of
this innovative raw material, enabling formulators to incorporate this promising bioactive into their product lines.
PCM
References 1. Macrophi Inc. Enhancement of keratinocyte barrier function by LPS. Macrophi Research Report [Internet]. 2023.
https://www.macrophi.
co.jp/report/a06.html
2. Okutomi T, Satoh T, Yamamoto Y, Koike K, Tokunaga K, Morita H et al. Immunopotentiator from Pantoea agglomerans prevents atopic dermatitis induced by Dermatophagoides farinae extract in NC/Nga mouse. Anticancer Res. 2015;35(8):4501–8
3. Gueniche A, Benyacoub J, Hacini-Rachinel F, Martin R, Rochat F, Malvy D et al. Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double- blind, placebo-controlled clinical study. Br J Dermatol. 2008;159(6):1357–63
Nucleus ■ LC3 ■
Figure 7: Increased LC3 fluorescence observed in LPS-treated HaCaT cells (10 µg/mL for 24h) vs. untreated controls, suggesting enhanced autophagy. Cells were stained with antibodies for LC3 (green) and nuclei (blue)
PERSONAL CARE MAGAZINE April 2026
4. Cork MJ, Danby SG, Ogg GS. Atopic dermatitis and filaggrin. Curr Opin Immunol. 2016;42:1–8
5. Nagase S, Ogawa Y, Takeuchi K, Hirose S, Nishida E, Kawai M et al. Propionibacterium acnes activates the IGF-1/IGF-1R system in the epidermis and induces keratinocyte
www.personalcaremagazine.com
THP1 + LPS (0.1%)
Growth (OD450)
Hyaluronic acid (ng/mL)
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