TRENDING TECHNOLOGIES 105


Improvement of skin texture in atopic disease area (after 4 weeks) Monitor A


Monitor B Monitor C


Monitor D


Start


4 weeks later


Lower arm


the dermis, it stimulates epidermal cells, which in turn transmit signals to the dermis.8


culture solution of macrophages stimulated by LPS to fibroblasts promotes their proliferation and enhances their capacities for synthesizing hyaluronic acid and elastin.


Promoting cellular turnover and epidermal renewal LPS contributes to long-term skin health and anti-ageing by promoting key cellular revitalization processes. Notably, it induces autophagy in keratinocytes, supporting the regulation of their turnover and maintaining epidermal renewal. In the epidermis, keratinocytes originate in


the basal layer and migrate upward, undergoing differentiation before being shed at the surface. This continuous renewal process is called turnover


Adding a


Outside of the elbow


Abdomen Figure 4: Visibly smoother skin appearance observed after four weeks of LPS application


and occurs about once a month in healthy skin. For turnover to proceed normally, keratinocytes must differentiate correctly as they migrate through the layers of the epidermis. Autophagy plays a crucial role in this


differentiation process. It is a mechanism of the degradation of intracellular proteins. Keratinocytes change the insides of the cells via autophagy. In the keratinocytes, autophagy is involved not only in turnover but also in melanin degradation and infection prevention.9 LPS is known to promote autophagy in macrophages and keratinocytes.10,11


Figure 7 shows


that the expression level of LC3 (Microtubule- associated protein light chain 3), a marker of autophagy, increases when human keratinocyte cell lines are treated with LPS. Thus, it is believed that the action of LPS on the skin also contributes


Improvement of atopic dermatitis itching 80


(A) Itching 60 40 ** 20 0 ** * ** **


100 80 60 40 20 0


0 2 4 LPS cream 0 2 4 (weeks) Placebo


(Comparison between groups) Significant difference


0 2 LPS cream


2 weeks later: improvement 4 weeks later: improvement


Figure 5: In vivo study showing reduced itch scores following LPS application in subjects with atopic-prone skin www.personalcaremagazine.com April 2026 PERSONAL CARE MAGAZINE 4 (weeks)


to the promotion of epidermis turnover.12 Furthermore, LPS has been shown to boost the


production of vital extracellular matrix proteins such as collagen and elastin. By stimulating the synthesis of these proteins, LPS contributes to improved skin firmness and reduced appearance of fine lines. Its multifaceted action positions LPS as a comprehensive ingredient for advanced formulations targeting visible signs of ageing.


Integrating LPS into advanced skin care Given its diverse benefits and unique mechanism of action, LPS is an ideal active ingredient for a wide range of personal care applications, particularly in advanced skin care and specialized treatments. ■ Anti-ageing formulations: Creams, serums,


Inner elbow


Visual analog score (VAS) for self-evaluation of itching in the lipopolysaccharide derived from Pantoes agglomerans (LPS) and placebo groups (B) Degree of itching


100 80 60 40 20 0


0 2 Placebo


2 weeks later: improvement 4 weeks later: worsening


4 (weeks)


VAS score (mm)


VAS score (mm)


VAS score (mm)


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