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as a central modulator of inflammaging. Recent reviews show that vitamin D signalling enhances Nrf2‑driven ROS detoxification, preserves mitochondrial function and maintains stratum corneum integrity under UV stress. In parallel, it rebalances cutaneous immune
responses, dampening chronic low-grade inflammation and senescence‑associated secretory phenotypes, thereby slowing wrinkle formation, pigmentary disorders and barrier decline associated with intrinsic and extrinsic ageing. It has photoprotective effects by enhancing
anti‑inflammatory actions, inhibiting DNA damage but inducing DNA repair mechanisms helping to maintain genomic stability.27
Vitamin E (tocopherols/ topcotrienols) Vitamin E is the primary lipid-soluble antioxidant in cell membranes and sebum, where it intercepts lipid peroxyl radicals before they propagate chain reactions that damage barrier lipids and collagen. UV exposure rapidly depletes cutaneous α-tocopherol; topical replenishment reduces erythema, limits MMP induction and improves smoothness, particularly when combined with vitamin C for redox recycling. By preserving membrane integrity, attenuating
oxidative stress and supporting barrier function, vitamin E targets hallmarks such as mitochondrial dysfunction and genomic instability, cellular senescence, affecting membrane integrity that underlie visible dryness, laxity and roughness.28,29,30 Vitamins are far from ‘old school’ in the era of
longevity science; they are core regulators of how skin ages over time. Deeply wired into pathways such as mitochondrial energy, DNA repair, epigenetic signalling and inflammaging, individual vitamins can influence several hallmarks of ageing simultaneously. Because these same molecules can also be
delivered in diverse topical applications—serums, creams, gels or sunscreens—they translate sophisticated hallmarks biology into practical routines that maintain healthy skin conditions. Their unique combination of mechanistic depth and high consumer trust makes vitamins a natural first choice for future skin longevity strategies. Vitamin B3 stands out as the most
comprehensively validated vitamin in skin care, with robust in vitro and clinical data for strengthening the barrier, reducing inflammation and dyschromia, and supporting cellular energy via NAD+
built‑in “vitamin cocktail” on its own. In biology, however, very few pathways are
powered by a single vitamin, which explains why combining B3 with C, E, pro-vitamin B5 or vitamin A derivatives often yields synergistic improvements in texture, tone and resilience. In nature, metabolic pathways frequently
involve several vitamins, which to a great extent explains why blends of vitamins can have synergistic effects. The inside‑outside approach will become more important, where targeted oral supplements are strategically combined with topical vitamin formulas to reinforce the same pathways in parallel.
PERSONAL CARE MAGAZINE April 2026
Conclusion In the era of peptides, exosomes and growth factors, vitamins will retain their critical role in skin longevity. They are deeply wired into skin biology, can modulate multiple ageing hallmarks, and come with an exceptional safety and familiarity profile that consumers already trust. Their formulation flexibility—from light serums
to rich creams and cleansing formats—means they can anchor virtually any longevity-driven concept, while single powerhouses like nicotinamide or smart vitamin blends address several pathways at once.
This unique mix of scientific depth, versatility . Its multitarget profile makes it feel like a
and credibility, positions vitamins as first‑line actives for future‑focused, genuinely effective, skin longevity care.
PCM
References 1. Li X, Li C, Zhang Wet al. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduction and Targeted Therapy. 2023; 8, p. 239
2. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023; 186(2), pp. 243–278
3. Joshi M, Hiremath P, John J, Ranadive N, Nandakumar K, Mudgal, J. Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases.
Pharmacological Reports. 2023; 75(5), pp. 1096-1114
4. Bhutia SK. Vitamin D in autophagy signaling for health and diseases: Insights on potential mechanisms and future perspectives. The Journal of Nutritional Biochemistry. 2022; 99, p. 108841
5. Sorrenti V, Benedetti F, Buriani A, Fortinguerra S, Caudullo G, Davinelli S, Zella D, Scapagnini G. Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks. Pharmaceuticals. 2022; 15(8), p. 912
6. Samanta S. Vitamin D and immunomodulation in the skin: a useful affirmative nexus. Exploration of Immunology. 2021; 1, pp. 90-111
7. Ambagaspitiya SS, Appuhamillage GA, Wimalawansa SJ. Impact of Vitamin D on skin aging, and age-related dermatological conditions. Frontiers in Bioscience-Landmark. 2025; 30(1), p. 25463
8. Pavlovic V, Ciric M, Petkovic M, Golubovic M. Vitamin C and epigenetics: A short physiological overview. Open Medicine. 2023; 18(1), p. 20230688
9. Boyera N, Galey I, Bernard BA. Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International Journal of Cosmetic Science. 1998; 20(3), pp. 151–158
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