70 LIFESTYLE COSMETICS Control Daylight


NightessenceTM + daylight


0.1%


+38%*** Figure 6: ROS detection on keratinocytes exposed to artificial daylight and treated with Nightessence or a benchmark at 0.1%. Control UVB NightessenceTM 0.1% + UVB Lavender macerate 0.1% + UVB


-34%*** ***: against daylight without treatment, with Student’s test


+20%*** Figure 7: Detection of dark CPDs on melanocytes 16 hours after UVB exposure and treated with Nightessence or a benchmark at 0.1%.


cosmetic, overnight skin reset formulations, after-sun products against dark sun effect, daily care to protect against sun & light- induced oxidation, cosmetic concepts associated with social jetlag and neurocosmetic approach.


Ashland is launching Nightessence biofunctional during in-cosmetics Global, booth F40.


Acknowledgements We would like to thank the technical team in Sophia Antipolis, Florian Labarrade, Gregory Bressier, Corinne Coquet and Ashland Clinical research team in Shanghai, Rachel Zhao, Suzan Zhao, Xin Qu.


PC


References 1 Matsui MS, Pelle E, Dong K, Pernodet N.


Biological Rhythms in the Skin. Int J Mol Sci. 2016; 24:17(6).


2 Lee JH, et al. Melatonin protects skin keratinocyte from hydrogen peroxide-


D28-D0


6.00 4.00 2.00 0.00 -2.00 -4.00 -6.00 -8.00 -10.00


mediated cell death via the SIRT1 pathway, Oncotarget 2016; 7, 11


3 Slominski AT et al. Melatonin: A Cutaneous Perspective on Its Production, Metabolism, and Functions, J Invest Dermatol. 2018


4 Slominski AT, et al. Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin’s Neuroendocrine System, Advances in Anatomy, Embryology and Cell Biology 2012;212:1-115


5 Schallreuter KU, et al. Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol 2008; 17:139-140


6 Sanjay P. Chemiexcitation of Melanin Derivatives Induces DNA Photoproducts Long after UV Exposure. Science. 2015 Feb 20; 347(6224): 842–847.


7 https://news.yale.edu/2015/02/19/sunlight- continues-damage-skin-dark


8 https://www.the-scientist.com/daily-news/the- dark-side-of-melanin-35910


9 https://www.cbsnews.com/news/sun-damage- to-skin-continues-after-dark/


10 Lawrence KP, et al. The UV/Visible Radiation Boundary Region (385–405 nm) Damages Skin Cells and Induces “dark” Cyclobutane Pyrimidine Dimers in Human Skin in vivo, Nature, Scientific Reports, 2018 11 Giudice A et al. The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis, Molecules 2018, 23, 1308


12 https://www.health.harvard.edu/staying- healthy/blue-light-has-a-dark-side


13 Mintel study; UK: 962 female internet users aged 16+ who use facial skincare products (May 2018); female internet users aged 16+ (France: 1,034, Germany: 1,009, Italy: 1,017, Spain: 1,008); 2018: UK: 1,713 internet users aged 16+ who have experienced stress in the last 12 months (February 2018)


14 https://tinyurl.com/wnr7uov 15 https://www.healthline.com/health/clean- sleeping-is-the-new-clean-eating#1


ns


-316% ****


Placebo side NightessenceTM side **** Extremely significant, p<0.001 PERSONAL CARE EUROPE Figure 8: Dark circle improvement results. April 2020


∆MI Value


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