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抗ポリュ―ジョン 結論


過去 10 年間、 伴い、


しわの発生、 ど、


産業開発の容赦ない増大に


かつてないほどのピークに達しました。 したが って、 レス、


環境および大気汚染物質への暴露は、 皮膚は、


ROS の形成を通じて、 皮膚の斑点の形成、 効果的な表皮バリア機能損失な さまざまな悪影響を引き起こす可能性の


ある多数の潜在的に有毒な物質の影響を受 けています。


Kalilightは、 グルタチオンやシステインなどの


既知の抗酸化分子で官能化されたバイオミメ ティック ミネラル ヒドロキシアパタイトで構成 される活性剤です。 この複合体は、


アパタイトの機能的送達システムの特性と、


新的な作用を発揮します。 この活性成分は、 ってROSを減らし、 リアシステムを強化し、 美白作用 領域)


ヒドロキシ 安


定化されたグルタチオンおよびシステインの作 用によって決定される相乗効果に基づいて、





遍在する 生物学的作用によ 脂質過酸化を防ぎ、


(特に関連する色素沈着過剰のある で皮膚のシミや変色を大幅に減らし、


Kalilight コンプレックスは、 リスクの主な


要因に対する予防と直接的な活動の両方の 観点から、


参考文献 1. Mistry N. Guidelines for Formulating Anti-


Pollution Products. Cosmetics. December 2017; 4(4), 57


2. Whitehouse L. Anti Pollution and the Beauty Industry: Part I. Cosmetics Design-Europe.com. 2016


3. Pitman S. Euromonitor: The Evolution of Anti Pollution in Europe and North America: Part I. Cosmetics Design-Europe.com. 2017


4. Jo JH, Kennedy EA, Kong HH. Topographical and physiological differences of the skin mycobiome in health and disease. Virulence. 2017, 8, 324–333


5. Rembiesa J, Ruzgas T, Engblom J, Holefors A. The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims. Cosmetics. 2018, 5, 4


6. Dales R, Liu L, Wheeler AJ, Gilbert NL. Public health: Quality of indoor residential air and health. Can. Med. Assoc. J. 2008, 179, 147–152


7. Mancebo SE, Wang SQ. Recognizing the impact of ambient air pollution on skin health. J. Eur. Acad. Dermatol. Venereol. 2015, 29, 2326–2332


8. Lefebvre MA, Pham DM, Boussouira B, Bernard D, Camus C, Nguyen QL. Evaluation of the impact of urban pollution on the quality of skin: A multicentre study in Mexico. Int. J. Cosmet. Sci. 2015, 37, 329–338


9. Puri P, Nandar S, Kathuria S, Ramesh V. Effects of air pollution on the skin: A review. Indian J. Dermatol. Venerol. Leprol. 2017, 83, 415–423


10. Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, Bouffard GG, Blakesley RW, Murray PR, Green ED et al. Topographical and Temporal Diversity of the Human Skin Microbiome. Science. 2009, 324, 1190–1192


11. Grice EA, Segre JA. The skin microbiome. Nat. Rev. Microbiol. 2011, 9, 244–253


www.personalcaremagazine.com


バランスの取れた皮膚 そ


の明るさと 輝きを改善します。 実施された研究と観察された客観化に照らし て、


汚染関連の皮膚損傷を処置するた


めの斬新で革新的な多機能ソリューションを 表しています。


PC


12. Prescott SL, Larcombe D-L, Logan AC, West C, Burks W, Caraballo L, Levin M, Van Etten E, Horwitz P, Kozyrskyj A et al. The skin microbiome: Impact of modern environments on skin ecology, barrier integrity, and systemic immune programming. World Allergy Organ. J. 2017, 10, 29


13. He QC, Tavakkol A, Wietecha K, Begum-Gafur R, Ansari SA, Polefka T. Effects of environmentally realistic levels of ozone on stratum corneum function. Int. J. Cosmet. Sci. 2006, 28, 349–357


14. Krutmann J, Moyal D, Xiang LF, Seité S. Pollution and acne: Is there a link? Clin. Cosmet. Investig. Dermatol. 2017, 10, 199–204


14. Von Euw S, Wang Y, Laurent G, Drouet C, Babonneau F, Nassif N, Azaïs T. Bone mineral: new insights into its chemical composition. Nature Scientific Reports. Volume 9. Article number: 8456 (2019)


15. Legeros RZ, Legeros JP. In: Kokubo T (Ed.) Bioceramics and their clinical applications. Woodhead Publishing. 2008


16. Kattimani Kondaka S, Lingamaneni KS. Hydroxyapatite - Past, Present, and Future in Bone Regeneration. Bone and Tissue Regeneration Insights. 2016:7 9–19


17. Daugaard H, Elmengaard B, Bechtold JE, Jensen T, Soballe K. The effect on bone growth enhancement of implant coatings with hydroxyapatite and collagen deposited electrochemically and by plasma spray. J. Biomed. Mater. Res. Part A. 2010 Mar 1; 92(3): 913–921


18. Kawamata H, Fujita K, Ishizaki T, Hayman R, Kemi T. A now enamel restoring agent for use after bleaching. Journal of Dental Research. 2004. 83


19. Kaji F, Nakagawa S, Matsuda N, Watanabe M. The adsorption of unsaturated fatty acid on hydroxyapatite. Phosphorus Research Bulletin. January 2005. 19:147-151


20.Lamkhao S, Phaya M, Jansakun C, Chandet N, Thongkorn K, Rujijanagul G, Bangrak P, Randorn C. Synthesis of Hydroxyapatite with Antibacterial Properties Using a Microwave- Assisted Combustion Method. Scientific Reports. Volume 9, Article number: 4015 (2019)


21. Rastrelli F, Rastrelli G, Tosti G, Bifulco G, Rastrelli C. Biomimetic Hydroxyapatite, an Idea for Skin and Oral Defense. Cosmetics and Toiletries. Vol. 137, No. 6, June 2022


22.Rastrelli F, Bifulco G, Rastrelli C. Biomimetic booster for sustainable sunscreen. Personal Care Global. June 2022


23. Sonthalia S, Sarkar R. Glutathione for skin lightening: an update. Pigment International. January 2017 4(1):3


24.Chasseaud LF. The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv. Cancer Res. 1979;29:175–274


25.Burk RF. Glutathione-dependent protection by rat liver microsomal protein against lipid peroxidation. Biochim. Biophys. Acta. 1983;757(1):21–28


26. Villarama CD, Maibach HI. Glutathione as a depigmenting agent: an overview. Int. J. Cosmet. Sci. 2005; 27:147-53


27. Rastrelli G. A new synergic skin lightening and natural ingredient. SOFW Journal. 138- 7/2012


28.Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiageing and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology. 2017:10 147–153


29.Watanabe F, Hashizume E, Chan GP, Kamimura A. Skin-whitening and skin- condition-improving effects of topical oxidized glutathione: A double-blind and placebo-controlled clinical trial in healthy women. Clinical, Cosmetic and Investigational Dermatology. 2014:7 267–274


2023年5月 PERSONAL CARE 使用前 使用後 Figure 7: Kalilight activity @3% versus comparison cream: UV scan images 皮膚バ 使用前


Figure 6: Kalilight 活性 @3%: Fotofinder 画像 T° = 治療前


使用後 酸化スト より暗い色素沈着、 T° = 治療前 T1 = 6 週間後


91


T1 = 6 週間後


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