ANTI-POLLUTION CELL DIFFERENTIATION
In a contolled human dermal cell physical disruption assay, it was confirmed that Natralipid Advanced Omega Complex promoted increased cell differentiation after 48 hours. (Bar line = 400µm)
Figure 4: Controlled human dermal cell disruption and proliferation
content of flaxseed oil at 45%, balanced at a 4:1 ratio with LA (12%).11 In human clinical dietary intervention trials,
Ahiflower oil boosts circulating omega-3 EPA significantly, plus boosting omega-6 GLA and DGLA significantly.12
EPA is the dominant
omega-3 fatty acid in fish oil. GLA has decades of research supporting healthy skin and hormonal balance in dietary applications, plus noted anti-inflammatory support for skin in topical applications. Furthermore, in very recent mouse dietary
trials led by researchers at the University of Toronto’s Department of Nutritional Sciences, Ahiflower oil has been shown to form de novo omega-3 DHA (C22:6n-3) in key tissues like liver and brain about 80-90% as efficiently as purified marine-based DHA.13
A practical benefit of Ahiflower oil is that
due to its shorter chain omega-3/-6 fatty acid structure — no fatty acid has a carbon chain length longer than C18 — it is considerably more oxidatively stable than C20 and C22 omega-3 fatty acids in its natural triglyceride form. Furthermore, SDA has been shown to be
“as effective” as DHA in terms of key anti- inflammatory cell signaling pathways.14
This is
important when considering recent research identifying that dietary omega-3 EPA and DHA have protective anti-inflammatory effects against air pollution in the form of PM<2.5 particulates, which are among the most pernicious for penetrating the body’s defences. In a widely-covered 2017 animal study
looking at the effects of PM<2.5 air pollution on various organ systems,15
pro-inflammatory
effects were noted systematically. The particles themselves crossed the pulmonary blood barrier and migrated into the lung, liver, brain, and even testes of the exposed mice. While PM<2.5 air pollution particles are too
large to cross through healthy skin directly, they will exacerbate inflammatory effects in subjects who have persistently broken skin — eg through acne, atopic dermatitis, atopic eczema, etc — on top of already noted harmful effects from inhalation. However, an elevated omega-3 status
was shown in this study to have markedly protective effects. The authors concluded that elevated tissue levels of omega-3 fatty acids can effectively suppress fine particle- induced chronic inflammation, whether as an interventional or preventative measure.16
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www.personalcaremagazine.com
May 2023 PERSONAL CARE
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