SUN CARE Visible Light UVA/UVB Light UVA/UVB Light + Photobiome 3%


41


Figure 2: in vitro assay showing effect of 3% PhotoBiome


and semi-arid regions of the Near East and the Middle East (Gossypium herbaceum). Through a new technological platform of


Phyto-Cell Fusions, we combine a Phyto- Lipidic Fraction (PLF) of P. granatum with a Plasma Rich in Cell Factors (PRCF) of G. herbaceum. This way, we obtain a synergistic effect of prevention from photoageing by protecting the skin microbiota (Figure 1). The membrane lipids of P. granatum


(phospholipids, glycolipids etc.) have been maximized in this active ingredient, together with the plant’s antioxidants, the polyphenols and the hydroxybenzoic acids like ellagic acid. Furthermore, the Phyto-Lipidic Fraction


helps to encapsulate these antioxidants, and by fusing this fraction with the PRCF of G. herbaceum, the active molecules of this extremophile cotton (mainly, plant chromophores like polyphenols and other defence molecules) are also encapsulated in the lipids from P. granatum. This Phyto-Cell Fusion is complemented


with two more plant-derived substances: the fructooligosaccharides and the trehalose, sugars that help protecting the cell membranes of the skin microbiome against adverse conditions like dehydration. Therefore, the fructoologisaccharides and the trehalose also contribute to protecting the


TABLE 1: THE BACTERIAL POPULATION (CFU) OF DIFFERENT MICROORGANISMS WITH THE ACTIVE VERSUS CONTROL


CFU non-irradiated CFU with irradiation


% reduction CFU with sun exposure


CFU with irradiation + 20% PhotoBiome


Protecting effect of 20% PhotoBiome (% recovery of CFU count)


S.epidermidis 8.08 x 105 1.65 x 104


98% 1.15 x 105 12.5%


microbiota in front of sun radiation and as a consequence, to protecting our skin against its harmful effects.


Biological activity In vitro - protection of skin microbiota against sun radiation The bacterial population (CFU) of different microorganisms was quantified (S. epidermidis, M. luteus and B. pseudocatenolatum), each cultured in its specific culture medium in petri


UROLITHINS IN B. PSEUDOCATENULATUM


40 20 0


-20 -40


+34% + SR + SR +10% PHOTOBIOME -29% Figure 3: Effect of the sun radiation, and the active, on microbial metabolism (in vitro) www.personalcaremagazine.com May 2023 PERSONAL CARE


80 60 40 20 0


M. luteus 1.69 x 105 6.41 x 104


62% 2.01 x 105 >100%


B. pseudocatenolatum 4.99 x 106 3.76 x 106


25% 1.39 x 107 >100%


plates (serial dilutions followed by CFU count), in different conditions: non irradiated, and irradiating at 6J (broad spectrum: UV, visible and IR) in absence or presence of the active (at a 20% dosage, as the bacterial populations were very high, between 200,000 and 5,000,000 CFU). The sun radiation reduced the bacterial populations, while the active could maintain higher rates of survival. S. epidermidis was the bacteria with highest CFU count reduction


MELANIN SYNTHESIS IN M. FURFUR 18-fold


Non irradiated control


+ SR


+ SR +20% PHOTOBIOME


% Variation of Urolithins vs non irradiated


Melanin (µg/ml)


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