54 ANTI-POLLUTION


Ahiflower Oil is derived from the seeds of a plant called Buglossoides arvensis


Ahiflower human dermal skin science outcomes In 2022, Ahiflower oil’s topical anti- inflammatory activity was confirmed by researchers in South Korea affiliated with the Korean Dermatological Research Institute (KDRI). In in vitro experiments using human dermal fibroblast cells, an active complex using Ahiflower oil with meadowfoam (Limnanthes alba) seed oil (tradename: Natralipid® Advanced Omega Complex) demonstrated significant COX-2 inhibition effects, aquaporin-3 upregulation, and cytoprotection against pro-inflammatory and oxidative stress challenges. Also, in a controlled human dermal cell


disruption model, the Ahiflower complex demonstrated significant cell proliferation after 48 hours, suggesting a pro-collagen synthesis effect similar to findings using other SDA/GLA rich topical oils. Furthermore, in a human volunteer trial


(average age = 53, n=21) carried out using a 5% serum containing the same Ahiflower complex, KDRI found the serum was non-irritating and had significant anti-wrinkle, moisturization, and skin smoothness effects around the eyes and mouth at 28 days’ use. Reported significant anti-wrinkle/skin


smoothness (8-12%) and moisturization (18-40%) effects were comparable to early human volunteer trial effects using retinol-A and hyaluronic acid when they were first introduced into commerce. The results were presented originally in the July 2022 issue of Personal Care Global.17


Conclusion Ahiflower oil is the first non-GM plant-based omega-3-6-9 oil launched in a generation. It has a strong lineage of commercial development from prior plant-based SDA and GLA lipid sources dating back to the 1980s and 1990s which showed topical anti-inflammatory and collagen synthesis effects.


PERSONAL CARE May 2023 Ahiflower oil’s recognized capacity to


elevate circulating EPA levels in humans, coupled with SDA and GLA’s recognized topical anti-inflammatory activity, suggests a perhaps uniquely adaptive role in protecting skin cells in topical applications from myriad effects of air pollution, while offering complementary dietary support options.


References 1. Dijkhoff IM et al. Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies. Part Fibre Toxicol. 17, 35 (2020)


2. New York Times. Leading Causes of Death, 1970-74 https://archive.nytimes.com/www. nytimes.com/partners/aol/special/women/ data/70-74_f_2.htm


3. US Department of Health and Human Services. Reduce the lung cancer death rate — C-02. https://health.gov/ healthypeople/objectives-and-data/ browse-objectives/cancer/reduce-lung- cancer-death-rate-c-02


4. Dijkhoff IM. ibid. 5. Araviiskaia E, Berardesca E, Bieber T, Gontijo G, Sanchez Viera M, Marrot L, Chuberre B, Dreno B. The impact of airborne pollution on skin. J. Eur. Acad. Dermatol. Venereol. 2019 Aug;33(8):1496- 1505


6. Dijkoff IM. ibid. citing: Yang HJ, Lee SY, Suh DI, Shin YH, Kim BJ, Seo JH, Chang HY, Kim KW, Ahn K, Shin YJ, Lee KS, Lee CM, Oh SY, Kim H, Leem JH, Kim HC, Kim EJ, Lee JS, Hong SJ. The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods. BMC Pulm. Med. 2014 Jul 3;14:109


7. Chen H, Oliver BG, Pant A, Olivera A, Poronnik P, Pollock CA, Saad S. Particulate Matter, an Intrauterine Toxin Affecting Foetal Development and Beyond. Antioxidants (Basel). 2021 May 6;10(5):732 8. Burr GO, Burr MM. A new deficiency


disease produced by the rigid exclusion of fat from the diet. J Biol Chem (1929);82:345-6


PC


9. Guichardant M, Traitler H, Spielmann D, Sprecher H, Finot P-A. Stearidonic acid, an inhibitor of the 5-lipoxygenase pathway. A comparison with timnodonic and dihomogammalinolenic acid. Lipids. 1993(28):321-324


10. Coupland K. Composition for Treatment of Skin. US Patent No. 9,403,042 B2 (Aug 2, 2016). https://image-ppubs. uspto.gov/dirsearch-public/print/ downloadPdf/9403042


11. Cumberford G, Hebard A. Ahiflower oil: A novel non-GM plant-based omega-3+6 source. J. Lipid Technology. 2015 Sep;27(9):207-210


12. Lefort N. Dietary Buglossoides arvensis oil increases circulating n-3 polyunsaturated fatty acids in a dose-dependent manner and enhances lipopolysaccharide- stimulated whole blood interleukin-10—a randomized placebo-controlled trial. Nutrients. 2017; 9(261)


13. Metherel A. Blood and tissue DHA synthesis and turnover rates are faster in mice fed Ahiflower® oil compared to flaxseed oil using compound-specific isotopic analysis. Canadian Nutritional Society, presentation given at 2022 May 5-7 annual symposium


14. Sung J et al. Anti-Inflammatory effects of stearidonic acid mediated by suppression of NF-κB and MAP-kinase pathways in macrophages. Lipids. 2017


15. Li X-Y, Hao L, Liu Y-H, Chen C-Y, Pai VJ, Kang JX. Protection against fine particle-induced pulmonary and systemic inflammation by omega-3 polyunsaturated fatty acids, Biochimica et Biophysica Acta (BBA) - General Subjects. Volume 1861, Issue 3, 2017, Pages 577-584


16. Li XY 2017, ibid. 17. Personal Care Global. July 2022


www.personalcaremagazine.com


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