SKIN CARE


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16. Teranishi Y et al. Int J Mol Sci. 2020; 21 17. Sashikawa-Kimura M et al. Int J Mol Sci. 2024; 25: 8737


18. Kondo H et al. Eur J Immunol. 1998; 28: 769-79 19. Imokawa G. Water and the Stratum Corneum (Volume 1). Chapter 3. In vitro and In Vivo Models. Bioengineering of Skin, ed. By Elsner, P, Berardesca, E and Maibach, HI. CRC Press 1994: 23-47


20. Imokawa G et al. J Disp Sci Tech. 1989; 10: 617-41 21. Imokawa G et al. J Invest Dermatol. 1986; 87: 758-61


250 200 150 100 50 0


POLG: Phytosteryl/Octyldodecyl Lauroyl Glutamate CER: Pseudo Ceramide HIRU: Hirudoid Urea: (NH2


)2 CO Treatment for 6 weeks


87


POLG


CER


HIRU


Urea


Figure 8: Comparison of the increase rates in skin surface hydration after six weeks of application of various skin care products on non-lesional skin of AD patients12,28,30,31


22. Imokawa G et al. J Clin Invest. 1994; 94: 89-96 23. Imokawa G et al. J Soc Cosmet Chem 1989; 40: 273-85


24. Imokawa G et al. J Invest Dermatol. 1991; 96: 845-51


25. Imokawa G, Ishida K. J Clin Exp Dermatol Res. 2014; 5: 206-18


26. Ishii H. Oleoscience. 2004; 4(3): 97-103 27. Ishii H et al. J Soc Cosmet Chem. 1996; 47: 351-62 28. Takada M et al. Int J Mol Sci. 2022; 23: 21


29. Nakamura T et al. Nishinihon J Dermatol. 1999; 61(5): 671-81


30. Mizutani H et al. Nishinihon J Dermatol. 2001; 63: 457-61


31. Yamanaka M et al. Skin Res. 2001; 43: 278-85 32. Kawai M et al. Nihon Hifuka Gakkai Zasshi. 1989; 99: 999-1006


33. Hata M et al. Lab Invest. 2002; 82: 1451-61 34. Leung DY. J Allergy Clin Immunol. 2000; 105: 860-76


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