SKIN CARE
5 4 3 2 1
0 0 3 Week 6 **** ****
80 70 60 50 40 30 20 10 0
Treatment for 6 weeks
85
3
2
1 POLG 3. ■ severe
2. ■ moderate 1. ■ mild
0. ■ slight -1. ■ deterioration
Week 3 3
2
18 2
0
Week 6 3
10 11 1
0
Figure 3: Clinical improvement effects of ceramide-mimetic moisturizing agent (POLG) containing nano-emulsion on AD skin.28 Overall clinical improvement was assessed at weeks 3 and 6. n = 25, ****p<0.0001 compared to week 0. All data was analysed using Dunn’s multiple comparison test
respectively (Figure 3). These improvements were statistically significant versus baseline at both time points (p < 0.0001) (Figure 3).
Comparison of the clinical improvement degree with other moisturizers We previously conducted clinical trials using creams or lotions containing pseudo-ceramide, urea, and mucopolysaccharides (HIRU) on the non-lesional forearm skin of AD patients, enabling comparison of clinical improvement scores. In a four-week trial,12
3 2 1
0 0 3 Week 6 ** ***
250 200 150 100 50 0
0 **
0
3
2
1 CER
0
3
2
1 HIRU
0
3
2
1 Urea
Figure 4: Comparison of clinical improvement degrees after six weeks of application of Eldew PS-203 (POLG) nano-emulsion, CER cream, HIRU cream, and urea cream on non-lesional skin of AD patients.12, 28, 30, 31
0
3 Week
Figure 5: Skin surface evaluation by Visioscan28 SESC: Scaliness, n = 25. SESM: Smoothness, n = 25, ***p<0.001, **p<0.01, *p<0.05 compared to week 0. All data were analysed using Tukey’s multiple comparison test and are presented as mean ± SD.
CER cream showed
50% marked, 35.7% moderate, 14.3% slight, and 0% no improvement. HIRU cream resulted in 0% marked, 15.4% moderate, 80.8% slight, and 3.9% no improvement. In a six-week trial29
, CER cream yielded
15.2% marked, 68.7% moderate, 3.7% slight, and 12.4% no improvement; HIRU cream gave 18.6%, 31.3%, 37.5%, and 12.6%, respectively. In another six-week trial comparing CER and urea creams,30,31
CER cream showed 12%
marked, 48% moderate, 40.3% slight, and 0% no improvement; urea cream showed 0%, 10%, 20%, and 70%, respectively. Based on these, POLG nano-emulsion
showed intermediate efficacy in the order: CER cream > POLG nano-emulsion > HIRU cream > urea cream. Its efficacy was equivalent to or better than HIRU cream, a widely used medical anti-atopic moisturizer in Japan, supporting its clinical benefit in improving atopic dry skin (Figure 4).
Skin surface evaluation using Visioscan28 Visioscan evaluation revealed that six- week treatment with POLG nano-emulsion
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significantly reduced skin surface scaliness and improved smoothness (SESC and SESM) (Figure 5), indicating visible improvement in roughened skin.
Corneocyte size, extent of excoriation, and Nile red staining28 Six weeks of POLG nano-emulsion application significantly increased corneocyte size (Figure 6A), suggesting a deceleration of epidermal turnover, which had previously been associated with reduced corneocyte size.32 Skin excoriation also significantly decreased
(Figure 6B), likely reflecting reduced scaling. Furthermore, a significant increase in Nile red staining indicated enhanced lipid envelope integrity (Figure 6C).
Effects of POLG nano-emulsion on capacitance and TEWL values after three and six weeks of treatment28 Treatment with POLG nano-emulsion significantly increased capacitance at both three and six weeks, indicating a marked improvement in SC hydration (Figure 7A). Although a slight but statistically significant increase in TEWL was
observed (averaging 8.03 g/m2 and 8.96 g/m2
/h),2,11 /h at three weeks /h at six weeks, corresponding to
118.7% and 111.6% of baseline, respectively), these values remained within the normal physiological range (<10 g/m2
and were considered
negligible (Figure 7B). When plotted on a reference chart for non- lesional AD skin, baseline values (capacitance:
˜30; TEWL: ˜7.5) indicated mild AD severity. After six weeks of treatment, capacitance
increased to ˜60 and TEWL to ˜8.0, reaching the range observed in healthy skin,11
thus
demonstrating functional recovery. A comparative analysis of POLG nano-
emulsion with CER cream, HIRU lotion, and urea cream showed that the 199.7% increase in SC hydration achieved with POLG nano-emulsion exceeded that of CER cream (175%) and HIRU lotion (157%) (Figure 8).23
Other studies reported
increases of 169% with CER and 150% with urea cream, while four-week studies demonstrated increases of 151% with CER and 126% with HIRU lotion.30,31
These findings underscore the superior
moisturizing efficacy of POLG nano-emulsion. Collectively, these results suggest that agents
October 2025 PERSONAL CARE
6
Improvement
SESC
Improvement rate (%)
SESC
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