TRENDING TECHNOLOGIES A DARK EYE CIRCLE


10 5 0


-5


-10 -15


Week 0 Week 4 Week 8 *


2.5 2


1.5 1


0.5 0


-0.5 -1


Week 0 Week 4 Week 8 Figure 5: Improvement of dark eye circles and dullness by topical application of glucosyl hesperidin4


hesperidin had an anti-dark circle effect. Also, it was found that application of


glucosyl hesperidin tended to amplify the increase in L* value and decrease in b* value, which indicates an improvement of dullness and sallowness (Figure 5B, 5C). These results show the potential of glucosyl hesperidin as an active ingredient for combating dark circles and dullness in cosmetics.


Oral intake Subjects aware of fatigue and skin roughness ingested a food containing 500 mg glucosyl hesperidin or a placebo daily for twelve weeks,


and the Hb index, a* value and b* value of their right cheeks were measured using a spectrophotometer.4,5 Similarly to the HbO2


B DULLNESS 1 +


0.5 0


-0.5 -1


+ -1.5 Week 0 Week 4 Week 8


Placebo (N=8) ■ 0.5 w/w % glucosyl hesperidin (N=6) ■ † p<0.10, * p<0.05 vs. Placebo


application, oral intake of glucosyl hesperidin can therefore improve skin conditions by enhancing blood flow throughout the body.


index, the Hb index


is also a parameter of dark circles, where an increase indicates improvement. By the ingestion of glucosyl hesperidin, the ∆Hb index (the change in Hb index) showed a significant increase compared to placebo, indicating improvement of dark circles (Figure 6A). Furthermore, ingestion of glucosyl hesperidin resulted in a significant increase in the ∆a* value, suggesting an effect on rosy complexion (Figure 6B). In addition to topical


Suppression of protein carbonylation and glycation Recently, in addition to poor circulation, protein denaturation caused by carbonylation and glycation has been reported to contribute to dark circles and dullness.6,7


Since hesperidin has


a suppressive effect of protein carbonylation and glycation,8,9


glucosyl hesperidin was


conjectured to have the same effect. The effect of glucosyl hesperidin on protein


C SALLOWNESS


49


www.personalcaremagazine.com


October 2025 PERSONAL CARE


∆HbO2


index


∆L* Value


∆b* value


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