TRENDING TECHNOLOGIES
a broader recognition of the role diet plays in skin health. As interest in whole-body wellness grows, nutricosmetics have gained traction for their ability to complement topical regimens. Although many nutrients are incorporated into supplements, relatively few have shown scientifically validated effects on the skin. Glucosyl hesperidin, manufactured by
Nagase Viita, is available in two functional grades: Alpha Glucosyl Hesperidin for cosmetics and Citrapeak for food. This study investigated the effects of both topical and oral applications on the skin, demonstrating that each method improves the reduction of dark circles and dullness by enhancing blood circulation, and suppressing protein carbonylation and glycation. These results highlight the potential of
glucosyl hesperidin to deliver synergistic benefits from both inside and outside the body. Importantly, glucosyl hesperidin is not only
effective but also environmentally conscious. It is derived from upcycled citrus fruits, such as fallen fruits, and produced using sustainable enzyme technology. The final compound is readily biodegradable, minimizing its environmental footprint and aligning with the industry’s movement toward greener formulations. Glucosyl hesperidin stands out as a powerful
ingredient for modern personal care, uniting holistic benefits, versatility and sustainability. Its dual-action functionality, supporting both topical and nutritional applications, makes it uniquely positioned to meet the growing demand for inside-out beauty solutions. Derived from upcycled citrus and produced
through eco-conscious enzyme technology, it not only promotes radiant, healthy-looking skin but also aligns with the industry’s shift toward holistic wellness and environmental responsibility. In a market seeking high-
WEEK 0 Placebo (N=17) ■ 0.5 w/w% glucosyl hesperidin (N=16) ■
200 100 0
-100
-200 -300 -400
Week 0 Week 4
51
Week 8 *
Figure 9: Improvement of visible pores by topical application of glucosyl hesperidin * p<0.05 vs. Week 0
performance ingredients with purpose, glucosyl hesperidin delivers on both science and sustainability for a better wellbeing and planet.
References 1. Knowledge Sourcing Intelligence. Global Nutricosmetics Market to expand at a CAGR of 6.2% to surpass US$14 billion by 2030. 10 February 2025. https://www.
einpresswire.com/article/784786505/ global-nutricosmetics-market-to-expand-
WEEK 8 PC
at-a-cagr-of-6-2-to-surpass-us-15-billion- by-2030
2. Garg A et al. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytotherapy Research. 2001;15 (8), 655-669
3. Tatefuji T et al. The effect of α-glucosyl- hesperidin on heat loss from the limb skin surface determined by thermography. Fragrance Journal. 1997; 25 (1), 91-97
4. Yoshizane C et al. Usefulness of glucosylated vitamins as ingredients for inner beauty. FOOD Style. 2024; 21, 28 (8), 25-30
5. Endo S et al. Dietary glucosyl hesperidin improves skin colour and skin conditions in women – Placebo-controlled double- blind comparative study. Japanese Pharmacology & Therapeutics. 2015; 43 (12), 1687-1699
6. Iwai I et al. Decrease in the skin transparency induced by protein carbonylation in the stratum corneum. Journal of SCCJ. 2008; 42 (1), 16-21
7. Zheng W et al. Research advances on the damage mechanism of skin glycation and related inhibitors. Nutrients, 14, 4588 (2022)
8. Fernando PDSM et al. Hesperidin protects human HaCaT keratinocytes from particulate matter 2.5-induced apoptosis via the inhibition of oxidative stress and autophagy. Antioxidants. 11, 1363 (2022)
9. Li D et al. Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation. Pharmaceutical Biology, 50 (12), 1531-1535 (2012)
Pore Score 716 457
Figure 10: Improvement of visible pores by topical application of glucosyl hesperidin (image from one subject)
www.personalcaremagazine.com
10. Yamashita Y et al. Relationship between opened facial pores and carbonylated protein/catalase activity in stratum corneum. Journal of SCCJ. 2010; 44 (3), 216-222
October 2025 PERSONAL CARE
0.5 W/W % GLUCOSYL HESPERIDIN
∆Pore score
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