42 TRENDING TECHNOLOGIES Unlike traditional ingredients, biomimetic


exosomes are derived from plants and designed to replicate the natural functions of human exosomes, providing a range of remarkable benefits for skin and hair health. Exosomes are nano-sized extracellular


vesicles responsible for cellular communication. These vesicles are found in nearly all cells and play an essential role in intercellular transport, carrying biomolecules like proteins, lipids, and RNA. They are naturally involved in a range of biological processes, from immune response to tissue repair. In cosmetic science, exosomes represent a breakthrough because they can carry active ingredients across cellular membranes, reaching deep layers where traditional products struggle to be effective. Indermal, the cosmetics division of


Nanovex Biotechnologies, has developed exosome technology that takes advantage of this natural compatibility by encapsulating active agents within biomimetic exosomes, which mimic the structure and function of naturally occurring exosomes. This innovation promotes deep penetration and gradual release of active ingredients, enabling enhanced bioavailability and stability, crucial for efficacy in both skin and hair applications .


Core advantages of biomimetic exosomes in skin care High concentration and potency Biomimetic exosomes offer an extremely high concentration, reaching up to 10^14 exosomes per ml, which is a million times greater than natural sources. This density maximizes cosmetic effectiveness.


Effective and non-invasive penetration These exosomes penetrate deeply into the skin in a non-invasive manner, ensuring that active ingredients reach their destination effectively without disrupting their molecular structure.


Figure 2: Fibroblast where the cell nucleus is stained with DAPI (blue) and the Biomimetic Exosome- Like are labelled with rhodamin (red)


Regenerative and anti-ageing properties Derived from plants, exosomes promote skin regeneration and help reduce signs of ageing, providing biocompatible benefits for skin health.


Natural cellular affinity They act as natural cellular communicators, allowing exosomes to effectively integrate with skin cells and function similarly to human exosomes, enhancing cellular interaction and response.


Surface proteins The proteins and peptides that coat the surface of exosomes help replicate the functions of natural exosomes, optimizing communication and interaction with skin cells.


60 50 40 30 20 10 0


Figure 3: Encapsulation efficiency - Total active concentration PERSONAL CARE October 2025


High-quality production process Manufactured to medical standards, these biomimetic exosomes ensure high consistency and quality in each batch, delivering stable and reproducible results.


Cellular affinity Exosome-like vesicles show cellular affinity as can be seen in Figure 2. Here we can see a fibroblast where the cell nucleus is stained with DAPI (blue) and the biomimetic exosome- like are labelled with rhodamin (red). This image proves that the exosome-like vesicles specifically target cells acting effectively as communicators like natural exosomes.


Plant-inspired design Indermal’s biomimetic exosomes are enriched


55.9


28.7


Exosome without protein/peptides


protein/peptides


Figure 4: Testing Z-potential of the vesicles proving that some proteins are located on the membrane


www.personalcaremagazine.com


Exosome with


Z-potential (mV)


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