50 TRENDING TECHNOLOGIES A DARK EYE CIRCLE 0.15 * 0.05 -0.05 -0.15 Week 0 Week 6 Week 12
-0.50 -1.00
Week 0 Week 6 Week 12 Figure 6: Improvement of skin conditions by repeated oral intake of glucosyl hesperidin4,5
carbonylation and glycation was examined using BSA (Bovine Serum Albumin) as a standard protein. To investigate the anti- carbonylation effect of glucosyl hesperidin, BSA was incubated with sodium hypochlorite, which induces carbonylation. Immunofluorescence staining of
carbonylated BSA was performed, and the fluorescence intensity was used to calculate the relative amount of carbonylated BSA. The addition of glucosyl hesperidin reduced carbonylated BSA in a dose-dependent manner (Figure 7). Next, to investigate its anti-glycation
effect, BSA was incubated with glucose and glucosyl hesperidin, and the relative amounts of carboxymethyllysine and pentosidine, which are representative markers of glycated proteins, were measured by immunofluorescence staining. Glucosyl hesperidin suppressed the production of these two glycated proteins (Figure 8). These results demonstrated the anti-
carbonylation and anti-glycation effects of glucosyl hesperidin, which is also considered to contribute to the improvement of dark circles and dullness, as well as addressing poor circulation.
14 12 10 8 6 4 2 0
Glucosyl hesperidin Glucose (moI/L)
- -
- 0.1 - 0.5
- 1
+ -
+ 0.1 Figure 8: Effect of glucosyl hesperidin on BSA glycation PERSONAL CARE October 2025
www.personalcaremagazine.com + 0.5
+ 1
† p<0.10, * p<0.05 vs. Placebo
Improvement of facial pores Pore enlargement is known to be caused by the overproduction and peroxidation of sebum, as well as hyperkeratosis. In addition, the correlation between the degree of pore enlargement and protein carbonylation in stratum corneum has been reported.10
It
was therefore hypothesized that glucosyl hesperidin could improve facial pores due to its antioxidant and anti-carbonylation effects.
Topical application To confirm the effect on pores, subjects applied a toner containing 0.5% glucosyl hesperidin or a placebo toner twice daily for eight weeks, and the number of visible pores (pore score) was counted using a skin image analysis software. In the group treated with glucosyl hesperidin, the pore score was significantly decreased after eight weeks of application, indicating an improvement in facial pores (Figures 9, 10). Glucosyl hesperidin is therefore effective in making pores appear less visible.
Conclusion Holistic beauty has become a core principle in shaping the future of skincare. Its philosophy not only emphasizes outward appearance, but
CARBOXYMETHYLLYSINE 3
2.5 2
1.5 1
0.5 0
Glucosyl hesperidin Glucose (moI/L)
- -
- 0.1 - 0.5
- 1
+ -
+ 0.1 + 0.5
+ 1
1.2 1
0.8 0.6 0.4 0.2 0
Sodium hypochlorite
Glucosyl hesperidin (w/v %)
- -
+ -
+ 0.001 + 0.01 + 0.1
Figure 7: Effect of glucosyl hesperidin on BSA carbonylation
also embraces the interconnected health of the body, mind, and lifestyle. Today, environmental responsibility is an
integral part of this vision, with a growing emphasis on sustainability that seeks to promote the wellbeing of both people and the planet.
The ‘beauty from within’ concept reflects PENTOSIDINE
1.00 0.50 0.00
B COMPLEXION *
0.50 0.00
-0.50 -1.00 -1.50
Week 0 Week 6 C SALLOWNESS
+ Week 12 Placebo (N=21) ■ 500 mg glucosyl hesperidin (N=21) ■
∆Hb index Fluorescence intensity (relative)
∆a* value
Fluorescence intensity (relative)
∆b* value Fluorescence intensity (relative)
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