PEPTIDES


103


Boosting botox treatments with peptide active


Cristina Bonell, Belén Aguirre, Gemma Mola, Raquel Delgado - Lubrizol


In contemporary society, the pursuit of youthful, wrinkle-free skin is more prevalent than ever. However, many beauty consumers remain hesitant to embrace dermo-aesthetic treatments due to concerns about their invasiveness. These individuals often prefer to stick to traditional topical beauty products, which they perceive as safer and less intimidating. Despite this, the growing dissemination


of information regarding dermo-aesthetic treatments and the compelling evidence of their anti-wrinkle effects have gradually built trust among consumers. Consequently, an increasing number of individuals are now opting for procedures like botulinum toxin type-A (BTA) injections, to combat and reduce the signs of ageing caused by repetitive facial movements.1 BTA treatments have gained popularity


due to their ability to deliver noticeable and almost immediate results. The toxin works by disrupting the formation of the SNARE complex in motor neurons, thereby inhibiting the release of acetylcholine, a neurotransmitter


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responsible for muscle contraction. This results in muscle paralysis and a reduction in the appearance of wrinkles. However, the efficacy of BTA diminishes


over time, typically lasting about three to four months. After this period, the toxin is metabolized and excreted from the body, causing the treated muscles to regain their ability to contract, and the signs of ageing to reappear.2,3


Given the temporary nature of


BTA treatments, there is a growing need for complementary solutions that can extend their effects. In recent years, Lipotec™ active ingredients has made significant strides in developing a cosmetic ingredient that mimics the biological pathway of BTA: Argireline® Amplified peptide. Unlike BTA, which destroys the SNARE complex, the peptide interferes with its assembly, thereby reducing acetylcholine release at the neuromuscular junction. In addition to its pre-synaptic effect, the


peptide also exerts a post-synaptic effect to promote muscle relaxation and an anti- senescence effect. Combined all together,


the novel peptide has been found to offer a quick and complete solution against facial expression muscle activity.4,6 Until now, the novel peptide has acted as a


solution for cosmetic users who prefer to avoid injections and stick to topical treatments. Yet could it also be used by BTA injection users who could incorporate the peptide into their skin care routine to extend the effects of the toxin? By combining BTA injections with the


topical application of the peptide active ingredient, we aim to demonstrate through clinical studies that the duration before the next toxin administration is needed can be significantly prolonged.


Methods and results Clinical efficacy of the novel peptide in the enhanced effects of BTA treatment To evaluate the synergistic effects of combining the peptide with BTA treatment, a clinical study was conducted. This study included 45 male and female participants, aged 35 to 60, with skin phototypes II to IV.


October 2025 PERSONAL CARE


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