48 TRENDING TECHNOLOGIES
Control ■ 0.01 w/v % glucosyl hesperidin ■ 0.01 w/v % commercial bath additive ■
22 21 20 19 0 10 * p<0.05 vs. Control 20 Time after cold water stress (min)
Figure 2: Warming effect of glucosyl hesperidin in a bath3,4
the big toe was measured using thermography. The bath with glucosyl hesperidin showed
a significantly higher warming effect compared to the control, which was also comparable to or higher than that of the bath with the commercial additive (Figure 2).
Oral intake Healthy subjects ingested a single dose of a beverage containing 50, 100 or 200 mg of glucosyl hesperidin, or a placebo beverage, and the blood flow in their faces and right hands was measured by laser doppler flowmetry.4 Ingestion of glucosyl hesperidin significantly
enhanced blood flow in a dose-dependent manner (Figures 3, 4). It has been reported that glucosyl hesperidin enhances the bioavailability
BEFORE INTAKE 15 MIN 30 * *
* *
1.0 0.5 0.0
-0.5 -1.0 -1.5
0 15 FACE
** **
** **
* *
** **
** **
* *
-0.5 -1.0 -1.5
30 45 60 (min) 0 15 30
Figure 3: Improvement of blood flow by a single oral dose of glucosyl hesperidin4 p<0.01 vs. 0 mg
of nitric oxide, a known vasodilator, which is considered a mechanism underlying the increase in blood flow. These studies demonstrated that glucosyl hesperidin stimulates blood circulation similarly to hesperidin, both by topical and oral application, and therefore, it was expected to be effective against skin problems caused by poor circulation, such as dark circles and dullness.
Improvement of skin dullness and dark circles Topical application To evaluate the effect of glucosyl hesperidin on dark circles and dullness, subjects with dull skin applied a toner containing 0.5% glucosyl hesperidin or a placebo toner twice a day for
30 MIN eight weeks, and the HbO2 45 60 (min) † p<0.10, * p<0.05, ** index, L* value and
b* value around their eyes were measured using a spectrophotometer, as parameters of dark circles, dullness and sallowness, respectively.4 The change in each parameter was
calculated from the value before and after application, and stratified analysis was performed by dividing the subjects into two groups based on their initial b* value. As a result of the stratified analysis, in subjects with higher b* value, a decrease in the HbO2
index was
observed in the placebo group, indicating that the dark circles became more visible (Figure 5A). On the other hand, there was no decrease
in the group treated with glucosyl hesperidin which showed a significant difference compared to the placebo, suggesting that glucosyl
TIME AFTER INTAKE 45 MIN
60 MIN
1.0 0.5 0.0
0 mg ■ 50mg ■ 100mg ■ 200mg ■ RIGHT HAND
** +
* *
Figure 4: Improvement of blood flow by a single oral dose of glucosyl hesperidin (image from one subject) PERSONAL CARE October 2025
www.personalcaremagazine.com
PLACEBO
200MG GLUCOSYL HESPERIDIN
Surface temperature (°C)
∆Blood flow (A.U.U)
∆Blood flow (A.U.U)
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