60 EYE AREA CARE
support of local agriculture and economy are the pillars. ■ Transparent production: the Italian production is a guarantee of ethical sustainability.
Development Within this context, with the rising demand for sustainable and biotech-driven beauty solutions, Roelmi HPC introduces SeidoTech® Lux, a cutting-edge biotechnological cosmetic active ingredient designed to rejuvenate and brighten the eye contour area. Derived from the bacterial fermentation of upcycled natural extracts sourced from Mediterranean Vitis vinifera leaves, it exemplifies the fusion of advanced science and eco-conscious innovation, delivering clinically proven results for a refreshed, radiant eye care. The probiotic strain used in this bioprocess is
Lactobacillus plantarum PBS067, a proprietary strain of Synbalance, part of the Roelmi Group. Selected through extensive academic research, the fermentation process has been carefully optimized by fine-tuning various parameters to maximize bacterial growth and bioactivity. The resulting fermentation produces a bioactive complex rich in polyphenols, polysaccharides, proteins, and fibres. These metabolites work synergistically on multiple skin layers, delivering enhanced efficacy. The eye contour is often the first part of
the face to show visible signs of ageing—such as fine lines, volume loss, dark circles, and puffiness—due to a combination of internal and external factors.7
Its treatment can be particularly
challenging, as this area requires solutions that are not only effective but also gentle, due to its unique structure and sensitivity.8 The skin around the eyes is among the thinnest in the body—just 0.3 to 0.5 mm thick— with very little subcutaneous fat and fewer sebaceous glands. This makes it more fragile and less protected, leading to a weaker skin barrier which increases the risk of dryness and irritation.6 In addition, natural facial expressions repeated stress to the tissues, speeding up the breakdown of collagen and elastin and contributing to the early appearance of wrinkles.9 External factors—such as pollution, UV
rays, and blue light from screens—further increase oxidative stress, damaging the skin and accelerating ageing in this already vulnerable area.10
The dense blood and lymphatic vessels
also make the eye contour prone to fluid buildup and vascular dark circles. The ingredient’s performance has been substantiated through a comprehensive research program, including in vitro studies and a large-scale clinical trial with distinct periocular concerns.
Mechanism of action The biotech ingredient works through a broad and effective mechanism of action, demonstrating a multi-targeted activity profile. It helps control melanin production, leading to a more even and radiant skin tone. It exhibits significant anti-glycation activity, reducing the buildup of advanced glycation end-products (AGEs) linked to skin ageing. Its antioxidant properties were demonstrated by a decrease in reactive oxygen species
PERSONAL CARE October 2025 * p<0.05 ** p<0.01 *** p<0.001
40 35 30 25 20 15 10 5 0
T0 +14.60% * Placebo ■ 1% SeidoTech Lux ■ **+17%
***
***
T28
T56
Figure 1: Dark brown circles intensity assessed on 40 subjects with dark brown circles, aged between 18 and 65 years old
* p<0.05 ** p<0.01 *** p<0.001
16 14 12 10 8 6 4 2 0
T0
(ROS) following UV-induced oxidative stress in skin cells. Moreover, it improves microcirculation by stimulating the formation of new capillaries, giving the skin a fresher and healthier look.
In vitro efficacy dossier In vitro studies have clearly demonstrated the various mechanisms of action of the ingredient. Thanks to its synergistic effect, it works on multiple levels at the same time, making it particularly effective and versatile in cosmetic applications for eye contouring.
Clinical study A comprehensive clinical study was conducted on 120 volunteers with different under-eye concerns: dark pigmented (dark brown) circles, vascular dark circles, and under-eye bags. The study evaluated the efficacy of the
biotechnological ingredient after 28 and 56 days of treatment, using both instrumental and clinical assessments.
Placebo ■ 1% SeidoTech Lux ■ ** -7.2% ***
-11%
**
**
T28
T56 Figure 2: Eye bags volume on 40 subjects with eye bags, aged between 18 and 65 years old
Dark circles colour intensity The intensity of pigmentation in dark circles was another critical factor evaluated. This was measured using the ITA (Individual Typology Angle), an established indicator of skin colour and brightness. The biotech ingredient demonstrated a
reduction in the pigmentation intensity of dark brown circles up to 17% after 56 days (Figure 1).
Under-eye bags volume The reduction of under-eye puffiness was assessed by measuring the volume of eye bags using the PrimosCR 3D imaging system. This advanced technology reconstructs the skin’s surface in three dimensions, allowing precise and objective evaluation of volume changes. The biotech ingredient results recorded to
a decrease of eye bags volume, respectively by 7.2% at T28 and by 11.0% at T56 (Figure 2). Skin radiance One of the key parameters evaluated was
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Eye bags volume (mm3
)
ITA°
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