EYE AREA CARE
* p<0.05 ** p<0.01 *** p<0.001 14
13 12 11 10 9 T0 T28 T56
Figure 3: Skin radiance on 40 subjects with eye bags, 40 subjects with vascular dark circles and 40 subjects with dark brown circles, aged between 18 and 65 years old
skin radiance, measured through the gloss parameter, which quantifies the skin’s ability to reflect light. Using a spectrophotometer/ colorimeter, this parameter was assessed by measuring the reflected light from the skin after it was illuminated by diffuse light. The biotech ingredient enhances skin brightness by +16.4% at T28 and by +24.1% at T56 (Figure 3). An expert scoring method was employed
using internal clinical scales to evaluate the visibility of under-eye concerns such as eye bags, brown dark circles, vascular dark circles, and signs of fatigue around the eye contour. This method provided an objective assessment of improvement after 56 days of treatment with the biotech ingredient. The results showed the following improvements compared to the placebo group, as follows. ■ Eye bags visibility: reduced in 53% of subjects (versus 20% placebo). ■ Vascular dark circles visibility: reduced in 58% of subjects (versus 25% placebo). ■ Dark brown circles visibility: reduced in 60% of subjects (versus 21% placebo). ■ Signs of fatigue around the eye contour: improved in 60% of subjects (versus 27% placebo). These results substantiate the
multifunctional efficacy of the biotechnological ingredient, demonstrating its ability to target the primary mechanisms underlying visible periocular concerns. Through measurable improvements in pigmentation reduction, attenuation of under-eye puffiness, enhancement of skin radiance, and alleviation of perceived fatigue, the ingredient provides a comprehensive approach to periocular skin rejuvenation. The consistent improvements observed
across all evaluated parameters over an eight- week treatment period support its role as a clinically validated, multi-target active suitable for advanced cosmetic formulations.
Conclusion The development of the biotech ingredient
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highlights the transformative potential that the precision fermentation technology can have in the cosmetic industry. By leveraging probiotic strains to ferment upcycled matrixes, a multifunctional bioactive complex that addresses key mechanisms underlying periocular skin concerns has been created. This biotechnological approach not only enhances the efficacy and safety of the ingredient but also reinforces a sustainable production model aligned with circular bioeconomy principles. The multifunctional profile of the biotech
ingredient has been demonstrated through in vitro and clinical studies, showing activity on key mechanisms involved in periocular skin concerns, including melanogenesis, glycation, oxidative stress, and microcirculation. The ingredient offers a targeted solution for improving the appearance of dark circles, puffiness, and overall skin tone around the eyes. Beyond efficacy, this ingredient embodies
a new generation of cosmetic actives designed with environmental flagship at their core. The use of agricultural by-products as fermentation substrates, combined with a low-waste production process, significantly reduces the environmental impact compared to conventional actives derived from virgin botanical resources. Its sustainable production process and
broad efficacy make it a technically sound option for formulators seeking performance- driven actives with low environmental impact. Ultimately, the ingredient represents a
convergence of biotechnology, sustainability, and clinically proven efficacy, offering to formulators and branded companies a high-value opportunity for the increasingly demanding of visible results and responsible innovation. Its success underscores the broader role of precision fermentation as a strategic tool for shaping the future of cosmetic science and sustainable ingredient development.
References 1. Grand View Research. Biotechnology Market Size, Share & Trend Analysis By Technology (Nanobiotechnology, DNA Sequencing, Cell-based Assays), By Application (Health, Bioinformatics), By Region, And Segment Forecasts, 2024 – 2030
2. Grand View Research. Biotech Ingredients Market Size, Share & Trends Analysis Report By Product (Flavors (By Source, By Product, By Application)), Fragrances, Active Cosmetic Ingredients), By Region, And Segment Forecasts, 2024 – 2030
3. Zappelli C, Barbulova A, Apone F, Colucci G. Effective Active Ingredients Obtained through Biotechnology. Cosmetics. 2016; 3(4), 39
4. García Méndez MG, Morales Martínez TK, Ascacio Valdés JA, Chávez González ML, Flores Gallegos AC, Sepúlveda L. Application of Lactic Acid Bacteria in Fermentation Processes to Obtain Tannases Using Agro-Industrial Wastes. Fermentation. 2021; 7(2), 48
5. Khayatan D, Nouri K, Momtaz S, Roufogalis BD, Alidadi M, Jamialahmadi T, Abdolghaffari AH, Sahebkar A. Plant-Derived Fermented Products: An Interesting Concept for Human Health. Current Developments in Nutrition. 2024; 8(5), 102162
6. Lambros V. The aging periorbital region. Clin Plast Surg. 2015; Apr;42(2):1–9
7. Sundaram H, Beer K. Periorbital rejuvenation: an evidence-based review. J Drugs Dermatol. 2015 Sep;14(9):1049–56
8. Watanabe A, Tsujimura H, Kobayashi H et al. Morphological and functional features of periorbital skin: a review. J Cosmet Dermatol. 2011; Sep;10(3):204–10
9. Duteil L, Cardot-Leccia N, Maubert Y et al. Environmental factors and skin aging: the role of pollution, blue light, and infrared radiation. J Dermatol Sci. 2019; Oct;96(1):16–22
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10. Sarkar R et al. Periorbital hyperpigmentation: a comprehensive review. J Clin Aesthet Dermatol. 2016 Jan 1;9(1):49–55
October 2025 PERSONAL CARE *** *** *** ***
+16.4% **
Placebo ■ 1% SeidoTech Lux ■ +24.10% ***
61
Gloss parameter (a.u.)
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