The Bioanalysis Glossary


297. monolith A solid support that consists of a single piece of porous material characterized by a bimodal pore size distribution (macroporous and mesoporous), which confers favorable mass transfer properties, a large surface area and low-pressure drops suitable for use in analytical or purification methods.


298. monoclonal Pertaining to a specific protein from a single clone of cells, all molecules of this protein being the same.


299. monoclonal antibody Antibody produced by cloned cells derived from a single lymphocyte. Distinct from polyclonal antibodies, which are heterogeneous.


300. multi ascending dose (MAD; also known as ‘multiple


ascending dose’) A drug is given repeatedly at intervals shorter than those required to completely eliminate the drug from the previously given dose. This dosing is used to study the pharmacokinetics (PK)/ pharmacodynamics (PD) of multiple doses for safety and tolerability. The dose is increased over time to a predetermined maximal level.


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Bioanalysis (2020) 12(21) Suppl. 1


future science group


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